Anti-RBFOX1 Antibody (CAB7811)
- SKU:
- CAB7811
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-RBFOX1 Antibody |
| 抗体コード: | CAB7811 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RBFOX1 (NP_665900.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SKOV3, Mouse brain, Mouse heart, Mouse skeletal muscle, Rat brain, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RBFOX1 (NP_665900.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLAS QGVL LHPY GVPM IVPA APYL PGLI QGNQ EAAA APDT MAQP YASA QFAP PQNG IPAE YTAP HPHP APEY TGQT TVPE HTLN LYPP AQTH SEQS PADT SAQT VSGT ATQT DDAA PTDG QPQT QPSE NT |
| 遺伝子ID: | 54715 |
| Uniprot: | Q9NWB1 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 40kDa/42kDa/44kDa |
| 観察された分子量: | 43kDa |
| 同義語: | RBFOX1, 2BP1, A2BP1, FOX-1, FOX1, HRNBP1 |
| バックグラウンド: | The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. |
| NCBI Summary: | The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9NWB1 |
| NCBI GenInfo Identifier: | 215272410 |
| NCBI Gene ID: | 54715 |
| NCBI Accession: | NP_001135805.1 |
| UniProt Secondary Accession: | Q9NWB1,Q7Z7I7, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20, |
| UniProt Related Accession: | Q9NWB1 |
| Molecular Weight: | Observed: 43 kDaPredicted: 43 kDa |
| NCBI Full Name: | RNA binding protein fox-1 homolog 1 isoform 5 |
| NCBI Synonym Full Names: | RNA binding fox-1 homolog 1 |
| NCBI Official Symbol: | RBFOX1 |
| NCBI Official Synonym Symbols: | 2BP1; FOX1; A2BP1; FOX-1; HRNBP1 |
| NCBI Protein Information: | RNA binding protein fox-1 homolog 1 |
| UniProt Protein Name: | RNA binding protein fox-1 homolog 1 |
| UniProt Synonym Protein Names: | Ataxin-2-binding protein 1; Fox-1 homolog A; Hexaribonucleotide-binding protein 1 |
| Protein Family: | Berberine bridge enzyme |
| UniProt Gene Name: | RBFOX1 |
 | Western blot analysis of extracts of various cell lines, using RBFOX1 antibody (CAB7811) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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