Anti-RBBP6 Antibody (CAB6966)
- SKU:
- CAB6966
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-RBBP6 Antibody |
| 抗体コード: | CAB6966 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RBBP6 (NP_116015.2). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | HL-60, Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RBBP6 (NP_116015.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSCV HYKF SSKL NYDT VTFD GLHI SLCD LKKQ IMGR EKLK AADC DLQI TNAQ TKEE YTDD NALI PKNS SVIV RRIP IGGV KSTS KTYV ISRT EPAM ATTK AVCK NTIS HFFY TLLL PL |
| 遺伝子ID: | 5930 |
| Uniprot: | Q7Z6E9 |
| セルラーロケーション: | Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus |
| 計算された分子量: | 13kDa/106kDa/197kDa/201kDa |
| 観察された分子量: | 160kDa |
| 同義語: | RBBP6, MY038, P2P-R, PACT, RBQ-1, SNAMA |
| バックグラウンド: | The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. |
| UniProt Protein Function: | RBBP6: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Nucleolus; Ubiquitin ligase Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; microtubule organizing center; chromosome Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: in utero embryonic development; multicellular organism growth; protein ubiquitination during ubiquitin-dependent protein catabolic process; embryonic organ development |
| NCBI Summary: | The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z6E9 |
| NCBI GenInfo Identifier: | 74762440 |
| NCBI Gene ID: | 5930 |
| NCBI Accession: | Q7Z6E9.1 |
| UniProt Secondary Accession: | Q7Z6E9,Q147T5, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8 Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4, |
| UniProt Related Accession: | Q7Z6E9 |
| Molecular Weight: | 1792 |
| NCBI Full Name: | E3 ubiquitin-protein ligase RBBP6 |
| NCBI Synonym Full Names: | retinoblastoma binding protein 6 |
| NCBI Official Symbol: | RBBP6 |
| NCBI Official Synonym Symbols: | PACT; MY038; P2P-R; RBQ-1; SNAMA |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RBBP6; protein P2P-R; RB-binding Q-protein 1; retinoblastoma-binding Q protein 1; proliferation potential-related protein; p53-associated cellular protein of testis; retinoblastoma-binding protein 6, isoform 3 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RBBP6 |
| UniProt Synonym Protein Names: | Proliferation potential-related protein; Protein P2P-R; Retinoblastoma-binding Q protein 1; RBQ-1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RBBP6 |
| UniProt Entry Name: | RBBP6_HUMAN |
 | Immunofluorescence analysis of A-549 cells using RBBP6 antibody (CAB6966). Blue: DAPI for nuclear staining. |
View AllClose