| UniProt Protein Function: | RASIP1: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 19q13.33 Biological Process: angiogenesis; branching morphogenesis of a tube; negative regulation of autophagy; regulation of GTPase activity; vasculogenesis |
| UniProt Code: | Q5U651 |
| NCBI GenInfo Identifier: | 74736209 |
| NCBI Gene ID: | 54922 |
| NCBI Accession: | Q5U651.1 |
| UniProt Secondary Accession: | Q5U651,Q6U676, |
| UniProt Related Accession: | Q5U651 |
| Molecular Weight: | 103,457 Da |
| NCBI Full Name: | Ras-interacting protein 1 |
| NCBI Synonym Full Names: | Ras interacting protein 1 |
| NCBI Official Symbol: | RASIP1 |
| NCBI Official Synonym Symbols: | RAIN |
| NCBI Protein Information: | ras-interacting protein 1 |
| UniProt Protein Name: | Ras-interacting protein 1 |
| Protein Family: | Ras-interacting protein |
| UniProt Gene Name: | RASIP1 |
| UniProt Entry Name: | RAIN_HUMAN |
