Anti-RASGRP2 Antibody (CAB15381)
- SKU:
- CAB15381
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-RASGRP2 Antibody |
抗体コード: | CAB15381 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RASGRP2 (NP_722541.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | 293T, LO2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RASGRP2 (NP_722541.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGT LDLD KGCT VEEL LRGC IEAF DDSG KVRD PQLV RMFL MMHP WYIP SSQL AAKL LHIY QQSR KDNS NSLQ VKTC HLVR YWIS AFPA EFDL NPEL AEQI KELK ALLD QEGN RRHS SLID IDSV PTYK WKRQ VTQR NPVG QKKR KMSL LFDH LEPM ELAE HLTY LEYR SFCK ILFQ DYHS FVTH GCTV DNPV LERF ISLF |
遺伝子ID: | 10235 |
Uniprot: | Q7LDG7 |
セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Peripheral membrane protein, cytosol, ruffle membrane, synapse, synaptosome |
計算された分子量: | 16kDa/69kDa/75kDa |
観察された分子量: | 69kDa |
同義語: | RASGRP2, CALDAG-GEFI, CDC25L |
バックグラウンド: | The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. |
UniProt Protein Function: | Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. |
NCBI Summary: | The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q7LDG7 |
NCBI GenInfo Identifier: | 74713056 |
NCBI Gene ID: | 10235 |
NCBI Accession: | Q7LDG7.1 |
UniProt Secondary Accession: | Q7LDG7,O00538, Q9UL65, A6NDC7, |
UniProt Related Accession: | Q7LDG7 |
Molecular Weight: | 69,320 Da |
NCBI Full Name: | RAS guanyl-releasing protein 2 |
NCBI Synonym Full Names: | RAS guanyl releasing protein 2 |
NCBI Official Symbol: | RASGRP2 |
NCBI Official Synonym Symbols: | CDC25L; CALDAG-GEFI |
NCBI Protein Information: | RAS guanyl-releasing protein 2 |
UniProt Protein Name: | RAS guanyl-releasing protein 2 |
UniProt Synonym Protein Names: | Calcium and DAG-regulated guanine nucleotide exchange factor I; CalDAG-GEFI; Cdc25-like protein; hCDC25L; F25B3.3 kinase-like protein |
Protein Family: | RAS guanyl-releasing protein |
UniProt Gene Name: | RASGRP2 |
UniProt Entry Name: | GRP2_HUMAN |
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