Anti-RASA4 Antibody (CAB9860)
- SKU:
- CAB9860
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-RASA4 Antibody |
抗体コード: | CAB9860 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, 293T, Mouse thymus, Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | HLPP TFHA VAFY VMDE DALS RDDV IGKV CLTR DTIA SHPK GFSG WAHL TEVD PDEE VQGE IHLR LEVW PGAR ACRL RCSV LEAR DLAP KDRN GTSD PFVR VRYK GRTR ETSI VKKS CYPR WNET FEFE LQEG AMEA LCVE AWDW DLVS RNDF LGKV VIDV QRLR VVQQ EEGW FRLQ PDQS KSRR HDEG NLGS LQLE VRLR DETV LPSS YYQP LVHL LCHE VKLG MQGP GQL |
遺伝子ID: | 10156 |
Uniprot: | O43374 |
セルラーロケーション: | Cell membrane, Cytoplasm, Peripheral membrane protein, cytosol |
計算された分子量: | 85kDa/90kDa |
観察された分子量: | 100kDa |
同義語: | RASA4, CAPRI, GAPL |
バックグラウンド: | This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. |
NCBI Summary: | This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43374 |
NCBI GenInfo Identifier: | 299829175 |
NCBI Gene ID: | 10156 |
NCBI Accession: | NP_001073346 |
UniProt Related Accession: | O43374 |
Molecular Weight: | ~ 85, 90kDa |
NCBI Full Name: | ras GTPase-activating protein 4 isoform 2 |
NCBI Synonym Full Names: | RAS p21 protein activator 4 |
NCBI Official Symbol: | RASA4 |
NCBI Official Synonym Symbols: | GAPL; CAPRI |
NCBI Protein Information: | ras GTPase-activating protein 4 |
UniProt Protein Name: | Ras GTPase-activating protein 4 |
UniProt Synonym Protein Names: | Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2 |
Protein Family: | Ras GTPase-activating protein |
UniProt Gene Name: | RASA4 |
UniProt Entry Name: | RASL2_HUMAN |
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