Anti-Ras Antibody (CAB4735)
- SKU:
- CAB4735
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-Ras Antibody |
抗体コード: | CAB4735 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Ras |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, A-549, SH-SY5Y, Mouse testis, Mouse brain, Mouse spleen, Rat lung |
免疫原: | A synthesized peptide derived from human Ras |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 4893 |
Uniprot: | P01111/P01112/P01116_ |
セルラーロケーション: | |
計算された分子量: | 18kDa |
観察された分子量: | 20KDa |
同義語: | ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6 |
バックグラウンド: | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] |
UniProt Protein Function: | NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: Golgi apparatus; membrane; plasma membrane Molecular Function:protein complex binding Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular |
NCBI Summary: | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] |
UniProt Code: | P01111 |
NCBI GenInfo Identifier: | 131883 |
NCBI Gene ID: | 4893 |
NCBI Accession: | P01111.1 |
UniProt Secondary Accession: | P01111,Q14971, Q15104, Q15282, |
UniProt Related Accession: | P01111 |
Molecular Weight: | 21,229 Da |
NCBI Full Name: | GTPase NRas |
NCBI Synonym Full Names: | neuroblastoma RAS viral oncogene homolog |
NCBI Official Symbol: | NRAS |
NCBI Official Synonym Symbols: | NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 |
NCBI Protein Information: | GTPase NRas |
UniProt Protein Name: | GTPase NRas |
UniProt Synonym Protein Names: | Transforming protein N-Ras |
Protein Family: | GTPase |
UniProt Gene Name: | NRAS |
UniProt Entry Name: | RASN_HUMAN |
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