Anti-RANBP2 Antibody (CAB18596)
- SKU:
- CAB18596
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-RANBP2 Antibody |
| 抗体コード: | CAB18596 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human RANBP2. |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human RANBP2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5903 |
| Uniprot: | P49792 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
 | Immunohistochemistry - RANBP2 Rabbit pAb (CAB18596) |
| 同義語: | ADANE, ANE1, IIAE3, NUP358, TRP1, TRP2 |
| バックグラウンド: | RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | RANBP2: a very large RAN-binding nucleoporin with E3 SUMO-protein ligase activity. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Forms a complex with SUMOylated RanGAP1 (the GTPase activating protein for Ran) that is required for efficient importin alpha/beta dependent nuclear import. May bind RNA or DNA. Component of the nuclear export pathway. Has a specific docking site for the nuclear export factor exportin-1. Contains a cyclophilin type peptidyl-prolyl cis-trans isomerase domain. A giant scaffolding protein that forms filaments extending from the nuclear pore into the cytoplasm. Regulates the localization of mitochondria in photosensory neurons. Deficits of RanBP2 downregulate glucose catabolism and energy homeostasis. Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 and PARK2. For some substrates, sumoylation and nuclear import are linked events. Sumoylates proteins including SP100 and HDAC4 deacetylase. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ligase; Adaptor/scaffold; Nuclear export; EC 5.2.1.8; SUMO conjugating system; Nucleoporin Chromosomal Location of Human Ortholog: 2q12.3 Cellular Component: nuclear membrane; mitochondrion; membrane; nuclear pore; cytosol; nuclear inclusion body Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; zinc ion binding; RNA binding; Ran GTPase binding; ligase activity Biological Process: mRNA transport; protein peptidyl-prolyl isomerization; viral reproduction; protein folding; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; negative regulation of glucokinase activity; protein sumoylation; protein import into nucleus; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport Disease: Encephalopathy, Acute, Infection-induced, Susceptibility To, 3 |
| NCBI Summary: | RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49792 |
| NCBI GenInfo Identifier: | 150418007 |
| NCBI Gene ID: | 5903 |
| NCBI Accession: | NP_006258.3 |
| UniProt Secondary Accession: | P49792,Q13074, Q15280, Q53TE2, Q59FH7, |
| UniProt Related Accession: | P49792 |
| Molecular Weight: | 24.8 kDa |
| NCBI Full Name: | E3 SUMO-protein ligase RanBP2 |
| NCBI Synonym Full Names: | RAN binding protein 2 |
| NCBI Official Symbol: | RANBP2 |
| NCBI Official Synonym Symbols: | ANE1; TRP1; TRP2; ADANE; IIAE3; NUP358 |
| NCBI Protein Information: | E3 SUMO-protein ligase RanBP2; P270; nucleoporin 358; nucleoporin Nup358; 358 kDa nucleoporin; ran-binding protein 2; transformation-related protein 2; nuclear pore complex protein Nup358; acute necrotizing encephalopathy 1 (autosomal dominant) |
| UniProt Protein Name: | E3 SUMO-protein ligase RanBP2 |
| UniProt Synonym Protein Names: | 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270 |
| Protein Family: | E3 SUMO-protein ligase |
| UniProt Gene Name: | RANBP2 |
| UniProt Entry Name: | RBP2_HUMAN |