Anti-Rad23A Antibody (CAB3188)
- SKU:
- CAB3188
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-Rad23A Antibody |
抗体コード: | CAB3188 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human Rad23A (NP_005044.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HL-60, OVCAR3, H460, Mouse heart, Mouse skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human Rad23A (NP_005044.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAVT ITLK TLQQ QTFK IRME PDET VKVL KEKI EAEK GRDA FPVA GQKL IYAG KILS DDVP IRDY RIDE KNFV VVMV TKTK AGQG TSAP PEAS PTAA PESS TSFP PAPT SGMS HPPP AARE DKSP SEES APTT SPES VSGS VPSS GSSG REED AAST LVTG SEYE TMLT EIMS MGYE RERV VAAL RASY NNPH RAVE YLLT GIPG SPEP EHGS VQES QVSE QPAT EAAG ENPL EFLR DQPQ FQNM RQVI QQNP ALLP ALLQ QLGQ ENPQ LLQQ ISRH QEQF IQML NEPP GELA DISD VEGE VGAI GEEA PQMN YIQV TPQE KEAI ERLK ALGF PESL VIQA YFAC EKNE NLAA NFLL SQNF DDE |
遺伝子ID: | 5886 |
Uniprot: | P54725 |
セルラーロケーション: | Nucleus |
計算された分子量: | 33kDa/39kDa |
観察された分子量: | 52kDa |
同義語: | RAD23A, HHR23A, HR23A |
バックグラウンド: | The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. |
UniProt Protein Function: | RAD23A: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Belongs to the RAD23 family. |
UniProt Protein Details: | Protein type:DNA-binding; DNA repair, damage Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:polyubiquitin binding; protein binding; single-stranded DNA binding Biological Process: nucleotide-excision repair; positive regulation of viral genome replication; regulation of proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012] |
UniProt Code: | P54725 |
NCBI GenInfo Identifier: | 1709983 |
NCBI Gene ID: | 5886 |
NCBI Accession: | P54725.1 |
UniProt Secondary Accession: | P54725,Q59EU8, Q5M7Z1, K7ESE3, |
UniProt Related Accession: | P54725 |
Molecular Weight: | 39,538 Da |
NCBI Full Name: | UV excision repair protein RAD23 homolog A |
NCBI Synonym Full Names: | RAD23 homolog A, nucleotide excision repair protein |
NCBI Official Symbol: | RAD23A |
NCBI Official Synonym Symbols: | HR23A; HHR23A |
NCBI Protein Information: | UV excision repair protein RAD23 homolog A |
UniProt Protein Name: | UV excision repair protein RAD23 homolog A |
Protein Family: | UV excision repair protein |
UniProt Gene Name: | RAD23A |
UniProt Entry Name: | RD23A_HUMAN |
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