Anti-Rad23A Antibody (CAB19884)[KO Validated]

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SKU:
CAB19884
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
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Description

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抗体名:Anti-Rad23A Antibody [KO Validated]
抗体コード:CAB19884
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant protein of human Rad23A.
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:293T
免疫原:Recombinant protein of human Rad23A.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:5886
Uniprot:P54725
セルラーロケーション:Nucleus
計算された分子量:33kDa/39kDa
観察された分子量:49KDa
Anti-Rad23A Antibody [KO Validated] (CAB19884)Western blot analysis of extracts from normal (control) and Rad23A knockout (KO) 293T cells, using Rad23A antibody (CAB19884) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:RAD23A, HHR23A, HR23A
バックグラウンド:The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
UniProt Protein Function:RAD23A: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Belongs to the RAD23 family.
UniProt Protein Details:

Protein type:DNA-binding; DNA repair, damage

Chromosomal Location of Human Ortholog: 19p13.2

Molecular Function:polyubiquitin binding; protein binding; single-stranded DNA binding

Biological Process: nucleotide-excision repair; positive regulation of viral genome replication; regulation of proteasomal ubiquitin-dependent protein catabolic process

NCBI Summary:The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
UniProt Code:P54725
NCBI GenInfo Identifier:1709983
NCBI Gene ID:5886
NCBI Accession:P54725.1
UniProt Secondary Accession:P54725,Q59EU8, Q5M7Z1, K7ESE3,
UniProt Related Accession:P54725
Molecular Weight:39,538 Da
NCBI Full Name:UV excision repair protein RAD23 homolog A
NCBI Synonym Full Names:RAD23 homolog A, nucleotide excision repair protein
NCBI Official Symbol:RAD23A  
NCBI Official Synonym Symbols:HR23A; HHR23A  
NCBI Protein Information:UV excision repair protein RAD23 homolog A
UniProt Protein Name:UV excision repair protein RAD23 homolog A
Protein Family:UV excision repair protein
UniProt Gene Name:RAD23A  
UniProt Entry Name:RD23A_HUMAN
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