Anti-Rad18 Antibody (CAB4339)
- SKU:
- CAB4339
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-Rad18 Antibody |
抗体コード: | CAB4339 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Rad18 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, A-549, MCF7, K-562, Mouse testis, Mouse brain, Mouse spleen, Rat testis |
免疫原: | A synthesized peptide derived from human Rad18 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 56852 |
Uniprot: | Q9NS91 |
セルラーロケーション: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
計算された分子量: | 56kDa |
観察された分子量: | 70KDa/90KDa |
同義語: | RNF73 |
バックグラウンド: | The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. |
UniProt Protein Details: | Protein type:DNA repair, damage; EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: XY body; replication fork; nucleus; chromatin Molecular Function:Y-form DNA binding; protein binding; zinc ion binding; ubiquitin protein ligase binding; damaged DNA binding; polyubiquitin binding; ligase activity Biological Process: negative regulation of DNA recombination; protein ubiquitination; spermatogenesis; DNA repair; response to UV |
NCBI Summary: | The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NS91 |
NCBI GenInfo Identifier: | 313104165 |
NCBI Gene ID: | 56852 |
NCBI Accession: | Q9NS91.2 |
UniProt Secondary Accession: | Q9NS91,Q58F55, Q9NRT6, |
UniProt Related Accession: | Q9NS91 |
Molecular Weight: | 495 |
NCBI Full Name: | E3 ubiquitin-protein ligase RAD18 |
NCBI Synonym Full Names: | RAD18 E3 ubiquitin protein ligase |
NCBI Official Symbol: | RAD18 |
NCBI Official Synonym Symbols: | RNF73 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18 homolog; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p |
UniProt Protein Name: | E3 ubiquitin-protein ligase RAD18 |
UniProt Synonym Protein Names: | Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RAD18 |
UniProt Entry Name: | RAD18_HUMAN |
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