Anti-RAB7B Antibody (CAB17855)
- SKU:
- CAB17855
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-RAB7B Antibody |
| 抗体コード: | CAB17855 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, Mouse testis, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human RAB7B (NP_001157994.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNPR KKVD LKLI IVGA IGVG KTSL LHQY VHKT FYEE YQTT LGAS ILSK IIIL GDTT LKLQ IWDT GGQE RFRS MVST FYKG SDGC ILAF DVTD LESF EALD IWRG DVLA KIVP MEQS YPMV LLGN KIDL ADRK VPQE VAQG WCRE KDIP YFEV SAKN DINV VQAF EMLA SRAL SRYQ SILE NHLT ESIK LSPD QSRS RCC |
| 遺伝子ID: | 338382 |
| Uniprot: | Q96AH8 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 23kDa |
 | Western blot - RAB7B Rabbit pAb (CAB17855) |
| 同義語: | RAB7, RAB7B |
| バックグラウンド: |
| UniProt Protein Function: | RAB7B: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 1q32 Cellular Component: Golgi apparatus; phagocytic vesicle membrane; lysosome; late endosome; trans-Golgi network; phagocytic vesicle Molecular Function:GTP binding Biological Process: negative regulation of toll-like receptor 9 signaling pathway; protein transport; small GTPase mediated signal transduction; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation; activation of NF-kappaB transcription factor |
| UniProt Code: | Q96AH8 |
| NCBI GenInfo Identifier: | 256985158 |
| NCBI Gene ID: | 338382 |
| NCBI Accession: | NP_796377 |
| UniProt Related Accession: | Q96AH8 |
| Molecular Weight: | |
| NCBI Full Name: | ras-related protein Rab-7b isoform a |
| NCBI Synonym Full Names: | RAB7B, member RAS oncogene family |
| NCBI Official Symbol: | RAB7B |
| NCBI Official Synonym Symbols: | RAB7 |
| NCBI Protein Information: | ras-related protein Rab-7b |
| UniProt Protein Name: | Ras-related protein Rab-7b |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB7B |
| UniProt Entry Name: | RAB7B_HUMAN |