Anti-RAB7 Antibody (CAB12308)
- SKU:
- CAB12308
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Autophagy
Description
| 抗体名: | Anti-RAB7 Antibody |
| 抗体コード: | CAB12308 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human RAB7 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, A-549, RD, Mouse kidney, Mouse heart, Rat liver, Rat lung, Rat heart |
| 免疫原: | A synthesized peptide derived from human RAB7 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 7879 |
| Uniprot: | P51149 |
| セルラーロケーション: | |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 23KDa |
 | Western blot - RAB7 Rabbit mAb (CAB12308) |
| 同義語: | PRO2706, RAB7 |
| バックグラウンド: | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Rab7: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosome; retromer complex; lysosomal membrane; late endosome; vacuolar membrane; pre-autophagosomal structure membrane; melanosome; phagocytic vesicle Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding Biological Process: protein transport; protein targeting to lysosome; early endosome to late endosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome to lysosome transport; endocytosis; protein to membrane docking; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption Disease: Charcot-marie-tooth Disease, Axonal, Type 2b |
| NCBI Summary: | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51149 |
| NCBI GenInfo Identifier: | 1709999 |
| NCBI Gene ID: | 7879 |
| NCBI Accession: | P51149.1 |
| UniProt Related Accession: | P51149 |
| Molecular Weight: | |
| NCBI Full Name: | Ras-related protein Rab-7a |
| NCBI Synonym Full Names: | RAB7A, member RAS oncogene family |
| NCBI Official Symbol: | RAB7A |
| NCBI Official Synonym Symbols: | RAB7; CMT2B; PRO2706 |
| NCBI Protein Information: | ras-related protein Rab-7a |
| UniProt Protein Name: | Ras-related protein Rab-7a |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB7A |
| UniProt Entry Name: | RAB7A_HUMAN |