Anti-RAB5A Antibody (CAB1180)[KO Validated]
- SKU:
- CAB1180
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-RAB5A Antibody [KO Validated] |
抗体コード: | CAB1180 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human RAB5A (NP_004153.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, PC-12, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human RAB5A (NP_004153.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MASR GATR PNGP NTGN KICQ FKLV LLGE SAVG KSSL VLRF VKGQ FHEF QEST IGAA FLTQ TVCL DDTT VKFE IWDT AGQE RYHS LAPM YYRG AQAA IVVY DITN EESF ARAK NWVK ELQR QASP NIVI ALSG NKAD LANK RAVD FQEA QSYA DDNS LLFM ETSA KTSM NVNE IFMA IAKK LPKN EPQN PGAN SARG RGVD LTEP TQPT RNQC CSN |
遺伝子ID: | 5868 |
Uniprot: | P20339 |
セルラーロケーション: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome membrane, Lipid-anchor, Melanosome, Membrane, cytosol, ruffle |
計算された分子量: | 22kDa/23kDa |
観察された分子量: | 22kDa |
同義語: | RAB5A, RAB5 |
バックグラウンド: | RAB5A (RAB5A, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAB5A include borna disease, and venezuelan equine encephalitis. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is RAB20. |
UniProt Protein Function: | RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family. |
UniProt Protein Details: | Protein type:G protein, monomeric, Rab; Motility/polarity/chemotaxis; G protein, monomeric; G protein Chromosomal Location of Human Ortholog: 3p24-p22 Cellular Component: zymogen granule membrane; protein complex; early endosome; dendrite; terminal button; phagocytic vesicle; cytosol; actin cytoskeleton; lipid raft; ruffle; synaptic vesicle; recycling endosome; cell soma; endocytic vesicle; perinuclear region of cytoplasm; axon; cytoplasm; melanosome; plasma membrane; endosome membrane; nerve terminal; endosome Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GDP-dissociation inhibitor binding Biological Process: regulation of long-term neuronal synaptic plasticity; intracellular protein transport; regulation of endosome size; early endosome to late endosome transport; positive regulation of smooth muscle cell proliferation; regulation of endocytosis; endocytosis; regulation of filopodium formation; blood coagulation; positive regulation of smooth muscle cell migration; Rab protein signal transduction; positive regulation of exocytosis |
UniProt Code: | P20339 |
NCBI GenInfo Identifier: | 1346958 |
NCBI Gene ID: | 5868 |
NCBI Accession: | P20339.2 |
UniProt Secondary Accession: | P20339,Q6FI44, B4DJA5, |
UniProt Related Accession: | P20339 |
Molecular Weight: | 22,178 Da |
NCBI Full Name: | Ras-related protein Rab-5A |
NCBI Synonym Full Names: | RAB5A, member RAS oncogene family |
NCBI Official Symbol: | RAB5A |
NCBI Official Synonym Symbols: | RAB5 |
NCBI Protein Information: | ras-related protein Rab-5A; RAS-associated protein RAB5A |
UniProt Protein Name: | Ras-related protein Rab-5A |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAB5A |
UniProt Entry Name: | RAB5A_HUMAN |