Anti-RAB4A Antibody (CAB6712)
- SKU:
- CAB6712
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RAB4A Antibody |
| 抗体コード: | CAB6712 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human RAB4A (NP_004569.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 22Rv1, NCI-H460, SKOV3, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human RAB4A (NP_004569.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSQT AMSE TYDF LFKF LVIG NAGT GKSC LLHQ FIEK KFKD DSNH TIGV EFGS KIIN VGGK YVKL QIWD TAGQ ERFR SVTR SYYR GAAG ALLV YDIT SRET YNAL TNWL TDAR MLAS QNIV IILC GNKK DLDA DREV TFLE ASRF AQEN ELMF LETS ALTG ENVE EAFV QCAR KILN KIES GELD PERM GSGI QYGD AALR QLRS PRRA QAPN AQEC GC |
| 遺伝子ID: | 5867 |
| Uniprot: | P20338 |
| セルラーロケーション: | Cytoplasm, Membrane, Peripheral membrane protein |
| 計算された分子量: | 24kDa |
| 観察された分子量: | 24kDa |
| 同義語: | RAB4A, HRES-1, HRES-1/RAB4, HRES1, RAB4 |
| バックグラウンド: | This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | Rab4: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 1q42-q43 Cellular Component: membrane; perinuclear region of cytoplasm; vesicle; endosome Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; protein transporter activity Biological Process: antigen processing and presentation; intracellular protein transport; metabolic process; regulation of endocytosis; Rab protein signal transduction |
| NCBI Summary: | This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P20338 |
| NCBI GenInfo Identifier: | 460018296 |
| NCBI Gene ID: | 5867 |
| NCBI Accession: | P20338.3 |
| UniProt Secondary Accession: | P20338,Q5T7P7, Q9BQ44, |
| UniProt Related Accession: | P20338 |
| Molecular Weight: | 213 |
| NCBI Full Name: | Ras-related protein Rab-4A |
| NCBI Synonym Full Names: | RAB4A, member RAS oncogene family |
| NCBI Official Symbol: | RAB4A |
| NCBI Official Synonym Symbols: | RAB4; HRES1; HRES-1; HRES-1/RAB4 |
| NCBI Protein Information: | ras-related protein Rab-4A; HTLV-1 related endogenous sequence |
| UniProt Protein Name: | Ras-related protein Rab-4A |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB4A |
| UniProt Entry Name: | RAB4A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RAB4A antibody (CAB6712) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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