Anti-RAB3GAP1 Antibody (CAB18587)
- SKU:
- CAB18587
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-RAB3GAP1 Antibody |
| 抗体コード: | CAB18587 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human RAB3GAP1. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HepG2, Jurkat, Mouse lung, Mouse brain, Rat brain |
| 免疫原: | Recombinant protein of human RAB3GAP1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 22930 |
| Uniprot: | Q15042 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 130kDa |
 | Western blot - RAB3GAP1 Rabbit pAb (CAB18587) |
| 同義語: | P130, RAB3GAP, RAB3GAP130, WARBM1, RAB3GAP1 |
| バックグラウンド: |
| UniProt Protein Function: | RAB3GAP1: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1). A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP catalytic subunit family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q21.3 Cellular Component: protein complex; cytoplasm Molecular Function:Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding Biological Process: regulation of GTPase activity; hypothalamus development; camera-type eye development; brain development; regulation of short-term neuronal synaptic plasticity; regulation of excitatory postsynaptic membrane potential Disease: Warburg Micro Syndrome 1 |
| NCBI Summary: | This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| UniProt Code: | Q15042 |
| NCBI GenInfo Identifier: | 55743118 |
| NCBI Gene ID: | 22930 |
| NCBI Accession: | NP_036365.1 |
| UniProt Related Accession: | Q15042 |
| Molecular Weight: | |
| NCBI Full Name: | rab3 GTPase-activating protein catalytic subunit isoform 2 |
| NCBI Synonym Full Names: | RAB3 GTPase activating protein catalytic subunit 1 |
| NCBI Official Symbol: | RAB3GAP1 |
| NCBI Official Synonym Symbols: | P130; WARBM1; RAB3GAP; RAB3GAP130 |
| NCBI Protein Information: | rab3 GTPase-activating protein catalytic subunit |
| UniProt Protein Name: | Rab3 GTPase-activating protein catalytic subunit |
| UniProt Synonym Protein Names: | RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130 |
| UniProt Gene Name: | RAB3GAP1 |
| UniProt Entry Name: | RB3GP_HUMAN |