Anti-PVRL4 Antibody (CAB16149)
- SKU:
- CAB16149
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PVRL4 Antibody |
| 抗体コード: | CAB16149 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-510 of human PVRL4 (NP_112178.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-510 of human PVRL4 (NP_112178.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSRY HRRK AQQM TQKY EEEL TLTR ENSI RRLH SHHT DPRS QPEE SVGL RAEG HPDS LKDN SSCS VMSE EPEG RSYS TLTT VREI ETQT ELLS PGSG RAEE EEDQ DEGI KQAM NHFV QENG TLRA KPTG NGIY INGR GHLV |
| 遺伝子ID: | 81607 |
| Uniprot: | Q96NY8 |
| セルラーロケーション: | Cell junction, Cell membrane, Secreted, Single-pass type I membrane protein, adherens junction |
| 計算された分子量: | 24kDa/55kDa |
| 観察された分子量: | 55kDa |
| 同義語: | NECTIN4, EDSS1, LNIR, PRR4, PVRL4, nectin-4 |
| バックグラウンド: | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. |
| UniProt Protein Function: | Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. |
| NCBI Summary: | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q96NY8 |
| NCBI GenInfo Identifier: | 74761016 |
| NCBI Gene ID: | 81607 |
| NCBI Accession: | Q96NY8.1 |
| UniProt Secondary Accession: | Q96NY8,Q96K15, B4DQW3, |
| UniProt Related Accession: | Q96NY8 |
| Molecular Weight: | 24,341 Da |
| NCBI Full Name: | Nectin-4 |
| NCBI Synonym Full Names: | nectin cell adhesion molecule 4 |
| NCBI Official Symbol: | NECTIN4 |
| NCBI Official Synonym Symbols: | LNIR; PRR4; EDSS1; PVRL4; nectin-4 |
| NCBI Protein Information: | nectin-4 |
| UniProt Protein Name: | Nectin-4 |
| UniProt Synonym Protein Names: | Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4 |
| UniProt Gene Name: | NECTIN4 |
| UniProt Entry Name: | NECT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PVRL4 antibody (CAB16149) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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