Anti-PVRL3 Antibody (CAB4597)

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SKU:
CAB4597
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NECTIN3
Synonyms:
CD113
Synonyms:
CDW113
Synonyms:
PPR3
Synonyms:
PRR3
Synonyms:
PVRL3
Synonyms:
PVRR3
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Description

抗体名:PVRL3 Rabbit pAb
抗体コード:CAB4597
サイズ:20uL, 50uL, 100uL
同義語:NECTIN3, CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRL3, PVRR3, nectin-3
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 127-366 of human PVRL3 (NP_001230215.1).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 127-366 of human PVRL3 (NP_001230215.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:SLND ATIT LHNI GFSD SGKY ICKA VTFP LGNA QSST TVTV LVEP TVSL IKGP DSLI DGGN ETVA AICI AATG KPVA HIDW EGDL GEME STTT SFPN ETAT IISQ YKLF PTRF ARGR RITC VVKH PALE KDIR YSFI LDIQ YAPE VSVT GYDG NWFV GRKG VNLK CNAD ANPP PFKS VWSR LDGQ WPDG LLAS DNTL HFVH PLTF NYSG VYIC KVTN SLGQ RSDQ KVIY ISAY NSVA SLNC
遺伝子ID:25945
Uniprot:Q9NQS3
セルラーロケーション:Cell junction, Cell membrane, Single-pass membrane protein, postsynaptic cell membrane, synapse
計算された分子量:39kDa/54kDa/61kDa
観察された分子量:Refer to figures
UniProt Protein Function:PVRL3: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane

Molecular Function:cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion

NCBI Summary:This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Code:Q9NQS3
NCBI GenInfo Identifier:74762752
NCBI Gene ID:25945
NCBI Accession:Q9NQS3.1
UniProt Secondary Accession:Q9NQS3,Q6NVZ3, Q8NC05, Q8WVU4, Q9BVA9, Q9Y412, E9PFR0
UniProt Related Accession:Q9NQS3
Molecular Weight:54,375 Da
NCBI Full Name:Nectin-3
NCBI Synonym Full Names:nectin cell adhesion molecule 3
NCBI Official Symbol:NECTIN3  
NCBI Official Synonym Symbols:PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3  
NCBI Protein Information:nectin-3
UniProt Protein Name:Nectin-3
UniProt Synonym Protein Names:CDw113; Nectin cell adhesion molecule 3
UniProt Gene Name:NECTIN3  
UniProt Entry Name:NECT3_HUMAN
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