Anti-PUMA Antibody (CAB3752)
- SKU:
- CAB3752
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PUMA Antibody |
抗体コード: | CAB3752 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human PUMA |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, A-549, NIH/3T3, K-562, LO2, Mouse lung, Mouse spleen, Rat liver |
免疫原: | A synthesized peptide derived from human PUMA |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 27113 |
Uniprot: | Q96PG8/Q9BXH1 |
セルラーロケーション: | |
計算された分子量: | 18kDa |
観察された分子量: | 18KDa/23KDa |
同義語: | JFY-1, JFY1, PUMA |
バックグラウンド: | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
UniProt Protein Function: | BBC3B: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. {ECO:0000269|PubMed:11463392}. Isoform 3 does not interact with BCL2. 4 isoforms of the human protein are produced by alternative splicing |
UniProt Protein Details: | Protein type:Apoptosis; Mitochondrial Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: lysosome; mitochondrion Molecular Function:ATPase binding; glycoprotein binding; protein binding Biological Process: apoptosis |
NCBI Summary: | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q96PG8 |
NCBI GenInfo Identifier: | 391738062 |
NCBI Gene ID: | 27113 |
NCBI Accession: | Q96PG8.2 |
UniProt Related Accession: | Q9BXH1,Q96PG8 |
Molecular Weight: | 20,532 Da |
NCBI Full Name: | Bcl-2-binding component 3 |
NCBI Synonym Full Names: | BCL2 binding component 3 |
NCBI Official Symbol: | BBC3 |
NCBI Official Synonym Symbols: | JFY1; PUMA; JFY-1 |
NCBI Protein Information: | bcl-2-binding component 3 |
UniProt Protein Name: | Bcl-2-binding component 3 |
UniProt Synonym Protein Names: | JFY-1; p53 up-regulated modulator of apoptosis |
Protein Family: | Bcl-2-binding component |
UniProt Gene Name: | BBC3 |
UniProt Entry Name: | BBC3B_HUMAN |
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