Anti-PTPRU Antibody (CAB8475)
- SKU:
- CAB8475
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPRU Antibody |
| 抗体コード: | CAB8475 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1184-1433 of human PTPRU (NP_001181930.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1184-1433 of human PTPRU (NP_001181930.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IALL PRNR DKNR SMDV LPPD RCLP FLIS TDGD SNNY INAA LTDS YTRS AAFI VTLH PLQS TTPD FWRL VYDY GCTS IVML NQLN QSNS AWPC LQYW PEPG RQQY GLME VEFM SGTA DEDL VARV FRVQ NISR LQEG HLLV RHFQ FLRW SAYR DTPD SKKA FLHL LAEV DKWQ AESG DGRT IVHC LNGG GRSG TFCA CATV LEMI RCHN LVDV FFAA KTLR NYKP NMVE TMDQ YHFC YDVA LEYL EGLE SR |
| 遺伝子ID: | 10076 |
| Uniprot: | Q92729 |
| セルラーロケーション: | Cell junction, Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 160kDa/161kDa/162kDa |
| 観察された分子量: | 180kDa |
| 同義語: | PTPRU, FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. |
| UniProt Protein Function: | PTPRU: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: integral to plasma membrane; plasma membrane; intercellular junction Molecular Function:protein binding; beta-catenin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: negative regulation of cell proliferation; organ regeneration; cell-cell adhesion; homotypic cell-cell adhesion; response to glucocorticoid stimulus; Wnt receptor signaling pathway through beta-catenin; cell differentiation; protein amino acid dephosphorylation; cell adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway; negative regulation of cell migration |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q92729 |
| NCBI GenInfo Identifier: | 229462800 |
| NCBI Gene ID: | 10076 |
| NCBI Accession: | Q92729.2 |
| UniProt Secondary Accession: | Q92729,O00197, P78399, Q59HA4, Q5SYU4, Q5SYU5, Q92735 Q92850, A6H8L1, |
| UniProt Related Accession: | Q92729 |
| Molecular Weight: | 161,648 Da |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase U |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, U |
| NCBI Official Symbol: | PTPRU |
| NCBI Official Synonym Symbols: | FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase U; PTP pi; pi R-PTP-Psi; protein-tyrosine phosphatase J; protein-tyrosine phosphatase pi; pancreatic carcinoma phosphatase 2; Receptor protein tyrosine phosphatase hPTP-J; protein-tyrosine phosphatase receptor omicron; receptor-type protein-tyrosine phosphatase psi |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase U |
| UniProt Synonym Protein Names: | Pancreatic carcinoma phosphatase 2; PCP-2; Protein-tyrosine phosphatase J; PTP-J; hPTP-J; Protein-tyrosine phosphatase pi; PTP pi; Protein-tyrosine phosphatase receptor omicron; PTP-RO; Receptor-type protein-tyrosine phosphatase psi; R-PTP-psi |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRU |
| UniProt Entry Name: | PTPRU_HUMAN |
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