Anti-PTPRO Antibody (CAB6958)

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SKU:
CAB6958
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-PTPRO Antibody
抗体コード:CAB6958
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human PTPRO (NP_109592.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:HT-29
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 30-300 of human PTPRO (NP_109592.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:FHVT VQDD NNIV VSLE ASDV ISPA SVYV VKIT GESK NYFF EFEE FNST LPPP VIFK ASYH GLYY IITL VVVN GNVV TKPS RSIT VLTK PLPV TSVS IYDY KPSP ETGV LFEI HYPE KYNV FTRV NISY WEGK DFRT MLYK DFFK GKTV FNHW LPGM CYSN ITFQ LVSE ATFN KSTL VEYS GVSH EPKQ HRTA PYPP QNIS VRIV NLNK NNWE EQSG NFPE ESFM RSQD TIGK EKLF HFTE ETPE IPSG NISS GWPD FNSS DYET TSQP YWW
遺伝子ID:5800
Uniprot:Q16827
セルラーロケーション:Membrane, Single-pass type I membrane protein
計算された分子量:43kDa/47kDa/67kDa/134kDa/138kDa
観察された分子量:150kDa
同義語:PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O
バックグラウンド:This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
UniProt Protein Function:PTPRO: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.48; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 12p13.3-p13.2|12p13-p12

Cellular Component: neuron projection; growth cone; lamellipodium; integral to plasma membrane; axon; apical plasma membrane; plasma membrane; integral to membrane; dendritic spine; lateral plasma membrane

Molecular Function:Wnt-protein binding; protein binding; protein homodimerization activity; phosphoric monoester hydrolase activity; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: lamellipodium biogenesis; monocyte chemotaxis; axon guidance; regulation of glomerular filtration; negative regulation of glomerular filtration; cell morphogenesis; protein amino acid dephosphorylation; glomerulus development

Disease: Nephrotic Syndrome, Type 6

NCBI Summary:This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
UniProt Code:Q16827
NCBI GenInfo Identifier:209572663
NCBI Gene ID:5800
NCBI Accession:Q16827.2
UniProt Secondary Accession:Q16827,Q13101, Q8IYG3, Q9UBF0, Q9UBT5, A0AV39,
UniProt Related Accession:Q16827
Molecular Weight:1216
NCBI Full Name:Receptor-type tyrosine-protein phosphatase O
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type, O
NCBI Official Symbol:PTPRO  
NCBI Official Synonym Symbols:NPHS6; PTPU2; GLEPP1; PTP-OC; PTP-U2; PTPROT; R-PTP-O  
NCBI Protein Information:receptor-type tyrosine-protein phosphatase O; PTP phi; PTPase U2; phosphotyrosine phosphatase U2; glomerular epithelial protein 1; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase
UniProt Protein Name:Receptor-type tyrosine-protein phosphatase O
UniProt Synonym Protein Names:Glomerular epithelial protein 1; Protein tyrosine phosphatase U2; PTP-U2; PTPase U2
Protein Family:Receptor-type tyrosine-protein phosphatase
UniProt Gene Name:PTPRO  
UniProt Entry Name:PTPRO_HUMAN
Anti-PTPRO Antibody (CAB6958)Western blot analysis of extracts of HT-29 cells, using PTPRO Antibody (CAB6958) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
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