Anti-PTPRE Antibody (CAB7209)
- SKU:
- CAB7209
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPRE Antibody |
| 抗体コード: | CAB7209 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HL-60, SW620, Mouse brain, Mouse spleen, Mouse lung, Rat brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human PTPRE (NP_006495.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LRGN ETTA DSNE TTTT SGPP DPGA SQPL LAWL LLPL LLLL LVLL LAAY FFRF RKQR KAVV STSD KKMP NGIL EEQE QQRV MLLS RSPS GPKK YFPI PVEH LEEE IRIR SADD CKQF REEF NSLP SGHI QGTF ELAN KEEN REKN RYPN ILPN DHSR VILS QLDG IPCS DYIN ASYI DGYK E |
| 遺伝子ID: | 5791 |
| Uniprot: | P23469 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasm, Single-pass type I membrane protein |
| 計算された分子量: | 71kDa/74kDa/80kDa |
| 観察された分子量: | 81kDa |
| 同義語: | PTPRE, HPTPE, PTPE, R-PTP-EPSILON |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. |
| UniProt Protein Function: | PTPRE: a cytoplasmic and transmembrane receptor protein tyrosine phosphatase that regulates IL-10 and TNFA biosynthesis, myelination and cell-matrix adhesion, overexpression reduces tumor development |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 10q26 Cellular Component: cytoplasm; nucleus; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: negative regulation of insulin receptor signaling pathway; protein amino acid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P23469 |
| NCBI GenInfo Identifier: | 126471 |
| NCBI Gene ID: | 5791 |
| NCBI Accession: | P23469.1 |
| UniProt Secondary Accession: | P23469,Q13345, Q5VWH3, Q5VWH4, Q96KQ6, |
| UniProt Related Accession: | P23469 |
| Molecular Weight: | 71,382 Da |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase epsilon |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type E |
| NCBI Official Symbol: | PTPRE |
| NCBI Official Synonym Symbols: | PTPE; HPTPE; R-PTP-EPSILON |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase epsilon |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase epsilon |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRE |
| UniProt Entry Name: | PTPRE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTPRE antibody (CAB7209) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using PTPRE antibody (CAB7209) at dilution of 1:100 (40x lens). |
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