Anti-PTPRB Antibody (CAB6957)
- SKU:
- CAB6957
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-PTPRB Antibody |
| 抗体コード: | CAB6957 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1976-2215 of human PTPRB (NP_001103224.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1976-2215 of human PTPRB (NP_001103224.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | INAS YIPG NNFR REYI VTQG PLPG TKDD FWKM VWEQ NVHN IVMV TQCV EKGR VKCD HYWP ADQD SLYY GDLI LQML SESV LPEW TIRE FKIC GEEQ LDAH RLIR HFHY TVWP DHGV PETT QSLI QFVR TVRD YINR SPGA GPTV VHCS AGVG RTGT FIAL DRIL QQLD SKDS VDIY GAVH DLRL HRVH MVQT ECQY VYLH QCVR DVLR ARKL RSEQ ENPL FPIY ENVN PEYH RDPV YSRH |
| 遺伝子ID: | 5787 |
| Uniprot: | P23467 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 214kDa/224kDa/249kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | PTPRB, HPTP-BETA, HPTPB, PTPB, R-PTP-BETA, VEPTP |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PTPRB: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 12q15 Cellular Component: integral to plasma membrane; receptor complex Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity Biological Process: dephosphorylation; phosphate metabolic process; protein amino acid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | P23467 |
| NCBI GenInfo Identifier: | 157952215 |
| NCBI Gene ID: | 5787 |
| NCBI Accession: | NP_001103224.1 |
| UniProt Secondary Accession: | P23467,Q14D85, Q3MIV7, B7ZKS8, B7ZKT0, C9JX87, F5H3G6 |
| UniProt Related Accession: | P23467 |
| Molecular Weight: | 224kDa |
| NCBI Full Name: | receptor-type tyrosine-protein phosphatase beta isoform a |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type B |
| NCBI Official Symbol: | PTPRB |
| NCBI Official Synonym Symbols: | PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase beta |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase beta |
| UniProt Synonym Protein Names: | Vascular endothelial protein tyrosine phosphatase; VE-PTP |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRB |
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