| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P35236 |
| NCBI GenInfo Identifier: | 20141721 |
| NCBI Gene ID: | 5778 |
| NCBI Accession: | P35236.3 |
| UniProt Secondary Accession: | P35236,Q53XK4, Q5SXQ0, Q5SXQ1, Q9BV05, B3KXE1, |
| UniProt Related Accession: | P35236 |
| Molecular Weight: | 52,284 Da |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 7 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 7 |
| NCBI Official Symbol: | PTPN7 |
| NCBI Official Synonym Symbols: | LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 7 |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 7 |
| UniProt Synonym Protein Names: | Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN7 |
| UniProt Entry Name: | PTN7_HUMAN |
