Anti-PTPN6 Antibody (CAB1446)
- SKU:
- CAB1446
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPN6 Antibody |
| 抗体コード: | CAB1446 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human PTPN6 (NP_002822.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BT-474, MCF7, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human PTPN6 (NP_002822.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LNCS DPTS ERWY HGHM SGGQ AETL LQAK GEPW TFLV RESL SQPG DFVL SVLS DQPK AGPG SPLR VTHI KVMC EGGR YTVG GLET FDSL TDLV EHFK KTGI EEAS GAFV YLRQ PYYA TRVN AADI ENRV LELN KKQE SEDT AKAG FWEE FESL QKQE VKNL HQRL EGQR PENK GKNR YKNI LPFD HSRV ILQG RDSN IPGS DYIN ANYI KNQL LGPD ENAK TYIA SQGC LEAT VNDF WQMA WQEN SRVI VMTT REVE KGRN KCVP YWPE VGMQ RAYG PYSV TNCG EHDT TEYK LRTL QVSP L |
| 遺伝子ID: | 5777 |
| Uniprot: | P29350 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 63kDa/67kDa/70kDa |
| 観察された分子量: | 68kDa |
| 同義語: | HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, CTCN6, PTPN6 |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. |
| UniProt Protein Function: | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29350 |
| NCBI GenInfo Identifier: | 131469 |
| NCBI Gene ID: | 5777 |
| NCBI Accession: | P29350.1 |
| UniProt Secondary Accession: | P29350,Q969V8, Q9UK67, A8K306, G3V0F8, |
| UniProt Related Accession: | P29350 |
| Molecular Weight: | 64 kDa |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 6 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 6 |
| NCBI Official Symbol: | PTPN6 |
| NCBI Official Synonym Symbols: | HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1 |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 6 |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 6 |
| UniProt Synonym Protein Names: | Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN6 |
 | Western blot analysis of extracts of various cell lines, using PTPN6 antibody (CAB1446) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of U2OS cells using PTPN6 antibody (CAB1446). Blue: DAPI for nuclear staining. |