Anti-PTPN3 Antibody (CAB6400)
- SKU:
- CAB6400
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPN3 Antibody |
| 抗体コード: | CAB6400 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PTPN3 (NP_001138840.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, BT-474, 293T, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PTPN3 (NP_001138840.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTSR LRAL GGRI NNIR TSEL PKEK TRSE VICS IHFL DGVV QTFK VTKQ DTGQ VLLD MVHN HLGV TEKE YFGL QHDD DSVD SPRW LEAS KAIR KQLK GGFP CTLH FRVR FFIP DPNT LQQE QTRH LYFL QLKM DICE GRLT CPLN SAVV LASY AVQS HFGD YNSS IHHP GYLS DSHF IPDQ NEDF LTKV ESLH EQHS GLKQ SEAE SCYI NIAR TLDF YGVE LHSG RDLH NLDL MIGI ASAG VAVY RKYI CTSF YPWV NILK ISFK RKKF FIHQ RQKQ AESR EHIV AFNM LNYR SCKN LWKS |
| 遺伝子ID: | 5774 |
| Uniprot: | P26045 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton |
| 計算された分子量: | 83kDa/88kDa/103kDa |
| 観察された分子量: | 103kDa |
| 同義語: | PTPN3, PTP-H1, PTPH1 |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PTPN3: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 9q31 Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm Molecular Function:protein binding; sodium channel regulator activity; phosphotyrosine binding; cytoskeletal protein binding; protein tyrosine phosphatase activity; ATPase binding Biological Process: negative regulation of mitotic cell cycle; protein amino acid dephosphorylation; negative regulation of membrane protein ectodomain proteolysis |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P26045 |
| NCBI GenInfo Identifier: | 229462761 |
| NCBI Gene ID: | 5774 |
| NCBI Accession: | P26045.2 |
| UniProt Secondary Accession: | P26045,A0AUW9, E7EN99, E9PGU7, |
| UniProt Related Accession: | P26045 |
| Molecular Weight: | 913 |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 3 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 3 |
| NCBI Official Symbol: | PTPN3 |
| NCBI Official Synonym Symbols: | PTPH1; PTP-H1 |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 3; protein-tyrosine phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 3 |
| UniProt Synonym Protein Names: | Protein-tyrosine phosphatase H1; PTP-H1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN3 |
| UniProt Entry Name: | PTN3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTPN3 antibody (CAB6400) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat brain using PTPN3 antibody (CAB6400) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using PTPN3 antibody (CAB6400) at dilution of 1:100 (40x lens). |
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