Anti-PTPN18 Antibody (CAB8487)
- SKU:
- CAB8487
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PTPN18 Antibody |
抗体コード: | CAB8487 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PTPN18 (NP_001135842.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-251MG, SW620 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PTPN18 (NP_001135842.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSRS LDSA RSFL ERLE ARGG REGA VLAG EFSK RCER YWAQ EQEP LQTG LFCI TLIK EKWL NEDI MLRT LKVT FQKE SRSV YQLQ YMSW PDRG VPSS PDHM LAMV EEAR RLQG SGPE PLCV HCSA GCGR TGVL CTVD YVRQ LLLT QMIP PDFS LFDV VLKM RKQR PAAV QTEE QYRF LYHT VAQM FCST LQNA SPHY QNIK ENCA PLYD DA |
遺伝子ID: | 26469 |
Uniprot: | Q99952 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 38kDa/50kDa |
観察された分子量: | 60kDa |
同義語: | PTPN18, BDP1, PTP-HSCF |
バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | BDP1: a member of the non-receptor protein tyrosine phosphatase (PTP) family. Contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 2q21.1 Molecular Function:protein binding Biological Process: protein amino acid dephosphorylation |
NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008] |
UniProt Code: | Q99952 |
NCBI GenInfo Identifier: | 215273871 |
NCBI Gene ID: | 26469 |
NCBI Accession: | Q99952.2 |
UniProt Secondary Accession: | Q99952,Q53P42, B4E1E6, |
UniProt Related Accession: | Q99952 |
Molecular Weight: | 38,476 Da |
NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 18 |
NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 18 |
NCBI Official Symbol: | PTPN18 |
NCBI Official Synonym Symbols: | BDP1; PTP-HSCF |
NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 18 |
UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 18 |
UniProt Synonym Protein Names: | Brain-derived phosphatase |
Protein Family: | Tyrosine-protein phosphatase non-receptor |
UniProt Gene Name: | PTPN18 |
UniProt Entry Name: | PTN18_HUMAN |
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