Anti-PTPN13 Antibody (CAB13005)
- SKU:
- CAB13005
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPN13 Antibody |
| 抗体コード: | CAB13005 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, A-549, U-87MG, Mouse kidney, Mouse lung, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QDEN YFKD ILSD NSGR EDSE NTFS PYQF KTSG PEKK PIPG IDVL SKKK IWAS SMDL LCTA DRDF SSGE TATY RRCH PEAV TVRT STTP RKKE ARYS DGSI ALDI FGPQ KMDP IYHT RELP TSSA ISSA LDRI RERQ KKLQ VLRE AMNV EEPV RRYK TYHG DVFS TSSE SPSI ISSE SDFR QVRR SEAS KRFE SSSG LPGV DETL SQGQ SQRP SRQY ETPF EGNL INQE IMLK RQEE ELMQ LQAK MALR QSR |
| 遺伝子ID: | 5783 |
| Uniprot: | Q12923 |
| セルラーロケーション: | Cell projection, Cytoplasm, Nucleus, cytoskeleton, lamellipodium |
| 計算された分子量: | 255kDa/274kDa/276kDa/277kDa |
| 観察された分子量: | 310kDa |
| 同義語: | PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. |
| UniProt Protein Function: | PTPN13: Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 4q21.3 Cellular Component: cytoplasm; lamellipodium; nucleus; plasma membrane Molecular Function:protein binding; protein tyrosine phosphatase activity Biological Process: protein amino acid dephosphorylation; regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q12923 |
| NCBI GenInfo Identifier: | 12643716 |
| NCBI Gene ID: | 5783 |
| NCBI Accession: | Q12923.2 |
| UniProt Secondary Accession: | Q12923,Q15159, Q15263, Q15264, Q15265, Q15674, Q16826 Q8IWH7, Q9NYN9, Q9UDA8, B2RTR0, |
| UniProt Related Accession: | Q12923 |
| Molecular Weight: | 277,508 Da |
| NCBI Full Name: | Tyrosine-protein phosphatase non-receptor type 13 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, non-receptor type 13 |
| NCBI Official Symbol: | PTPN13 |
| NCBI Official Synonym Symbols: | PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; hPTP1E; PTP-BAS |
| NCBI Protein Information: | tyrosine-protein phosphatase non-receptor type 13 |
| UniProt Protein Name: | Tyrosine-protein phosphatase non-receptor type 13 |
| UniProt Synonym Protein Names: | Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1 |
| Protein Family: | Tyrosine-protein phosphatase non-receptor |
| UniProt Gene Name: | PTPN13 |
 | Western blot analysis of extracts of various cell lines, using PTPN13 antibody (CAB13005) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of NIH-3T3 cells using PTPN13 Polyclonal Antibody (CAB13005) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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