Anti-PTGES Antibody (CAB18632)
- SKU:
- CAB18632
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| 抗体名: | Anti-PTGES Antibody |
| 抗体コード: | CAB18632 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human PTGES. |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, Mouse lung, Rat lung |
| 免疫原: | A synthetic peptide of human PTGES. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9536 |
| Uniprot: | O14684 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 17kDa |
 | Western blot - PTGES Rabbit pAb (CAB18632) |
| 同義語: | |
| バックグラウンド: |
| UniProt Protein Function: | PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. |
| UniProt Protein Details: | Protein type:EC 5.3.99.3; Nuclear envelope; Isomerase; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 9q34.3 Cellular Component: endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; integral to membrane Molecular Function:glutathione binding; prostaglandin-E synthase activity Biological Process: chronic inflammatory response; response to retinoic acid; cyclooxygenase pathway; response to lipopolysaccharide; prostaglandin biosynthetic process; signal transduction; response to organic cyclic substance; prostaglandin metabolic process; negative regulation of cell proliferation; response to cytokine stimulus; arachidonic acid metabolic process; response to calcium ion; acute inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14684 |
| NCBI GenInfo Identifier: | 4758910 |
| NCBI Gene ID: | 9536 |
| NCBI Accession: | NP_004869.1 |
| UniProt Secondary Accession: | O14684,O14900, Q5SZC0, |
| UniProt Related Accession: | O14684 |
| Molecular Weight: | 17kd |
| NCBI Full Name: | prostaglandin E synthase |
| NCBI Synonym Full Names: | prostaglandin E synthase |
| NCBI Official Symbol: | PTGES |
| NCBI Official Synonym Symbols: | PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1 |
| NCBI Protein Information: | prostaglandin E synthase |
| UniProt Protein Name: | Prostaglandin E synthase |
| UniProt Synonym Protein Names: | Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein |
| UniProt Gene Name: | PTGES |
| UniProt Entry Name: | PTGES_HUMAN |