Anti-PSRC1 Antibody (CAB5484)
- SKU:
- CAB5484
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-PSRC1 Antibody |
| 抗体コード: | CAB5484 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, HepG2, 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEDL EEDV RFIV DETL DFGG LSPS DSRE EEDI TVLV TPEK PLRR GLSH RSDP NAVA PAPQ GVRL SLGP LSPE KLEE ILDE ANRL AAQL EQCA LQDR ESAG EGLG PRRV KPSP RRET FVLK DSPV RDLL PTVN SLTR STPS PSSL TPRL RSND RKGS VRAL RATS GKRP SNMK RESP TCNL FPAS KSPA SSPL TRST PPVR GRAG PSGR AAAS EET |
| 遺伝子ID: | 84722 |
| Uniprot: | Q6PGN9 |
| セルラーロケーション: | Cytoplasm, cytoskeleton, spindle, spindle pole |
| 計算された分子量: | 16kDa/33kDa/35kDa/38kDa |
| 観察された分子量: | 39kDa |
| 同義語: | PSRC1, DDA3, FP3214 |
| バックグラウンド: | This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | PSRC1: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. Belongs to the PSRC1 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: microtubule cytoskeleton; nucleoplasm; spindle pole; spindle microtubule; cytoplasm; spindle; midbody; cytosol Molecular Function:protein binding; microtubule binding Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of transcription, DNA-dependent; positive regulation of microtubule polymerization; negative regulation of cell growth; mitotic metaphase plate congression; microtubule bundle formation |
| NCBI Summary: | This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q6PGN9 |
| NCBI GenInfo Identifier: | 74737651 |
| NCBI Gene ID: | 84722 |
| NCBI Accession: | Q6PGN9.1 |
| UniProt Secondary Accession: | Q6PGN9,Q5T2Z3, Q6ZTI8, Q71MG3, Q9BV77, |
| UniProt Related Accession: | Q6PGN9 |
| Molecular Weight: | 363 |
| NCBI Full Name: | Proline/serine-rich coiled-coil protein 1 |
| NCBI Synonym Full Names: | proline/serine-rich coiled-coil 1 |
| NCBI Official Symbol: | PSRC1 |
| NCBI Official Synonym Symbols: | DDA3; FP3214 |
| NCBI Protein Information: | proline/serine-rich coiled-coil protein 1; p53-regulated DDA3; differential display and activated by p53 |
| UniProt Protein Name: | Proline/serine-rich coiled-coil protein 1 |
| Protein Family: | Proline/serine-rich coiled-coil protein |
| UniProt Gene Name: | PSRC1 |
| UniProt Entry Name: | PSRC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PSRC1 antibody (CAB5484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human esophagus using PSRC1 antibody (CAB5484) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using PSRC1 antibody (CAB5484) at dilution of 1:100 (40x lens). |
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