Anti-PSME4 Antibody (CAB19873)[KO Validated]

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SKU:
CAB19873
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
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Description

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抗体名:Anti-PSME4 Antibody [KO Validated]
抗体コード:CAB19873
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human PSME4.
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa
免疫原:Recombinant protein of human PSME4.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:23198
Uniprot:Q14997
セルラーロケーション:Cytoplasm, Nucleus, Nucleus speckle, cytosol
計算された分子量:24kDa/113kDa/139kDa/211kDa
観察された分子量:211KDa
Anti-PSME4 Antibody [KO Validated] (CAB19873)Western blot analysis of extracts from normal (control) and PSME4 knockout (KO) HeLa cells, using PSME4 antibody (CAB19873) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:PSME4, PA200
バックグラウンド:
UniProt Protein Function:Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
UniProt Code:Q14997
NCBI GenInfo Identifier:163644283
NCBI Gene ID:23198
NCBI Accession:NP_055429.2
UniProt Secondary Accession:Q14997,Q1XBG4, Q1XBG5, Q1XBG6, Q2M1Z0, Q6IPR2, Q86XF8
UniProt Related Accession:Q14997
Molecular Weight:Calculated: 24kDa; 113kDa; 139kDa; 211kDaObserved: 211kDa
NCBI Full Name:proteasome activator complex subunit 4
NCBI Synonym Full Names:proteasome activator subunit 4
NCBI Official Symbol:PSME4  
NCBI Official Synonym Symbols:PA200  
NCBI Protein Information:proteasome activator complex subunit 4
UniProt Protein Name:Proteasome activator complex subunit 4
UniProt Synonym Protein Names:Proteasome activator PA200
Protein Family:Proteasome activator complex
UniProt Gene Name:PSME4  
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