Anti-PSMD3 Antibody (CAB2790)
- SKU:
- CAB2790
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
抗体名: | Anti-PSMD3 Antibody |
抗体コード: | CAB2790 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human PSMD3 |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | BT-474, SKOV3, 293T |
免疫原: | A synthetic peptide of human PSMD3 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5709 |
Uniprot: | O43242 |
セルラーロケーション: | |
計算された分子量: | 41kDa/60kDa |
観察された分子量: | 65kDa |
同義語: | PSMD3, P58, RPN3, S3, TSTA2 |
バックグラウンド: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. |
UniProt Protein Function: | PSMD3: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit S3 family. |
UniProt Protein Details: | Protein type:Protease; Proteasome complex Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: proteasome complex; nucleoplasm; membrane; cytoplasm; nucleus; cytosol Molecular Function:enzyme regulator activity Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012] |
UniProt Code: | O43242 |
NCBI GenInfo Identifier: | 20532405 |
NCBI Gene ID: | 5709 |
NCBI Accession: | O43242.2 |
UniProt Secondary Accession: | O43242,Q96EI2, Q9BQA4, B3KMW9, B4DT72, |
UniProt Related Accession: | O43242 |
Molecular Weight: | 534 |
NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 3 |
NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 |
NCBI Official Symbol: | PSMD3 |
NCBI Official Synonym Symbols: | S3; P58; RPN3; TSTA2 |
NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 3; proteasome subunit p58; 26S proteasome regulatory subunit S3; 26S proteasome regulatory subunit RPN3; tissue specific transplantation antigen 2 |
UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 3 |
UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58 |
Protein Family: | 26S proteasome non-ATPase regulatory |
UniProt Gene Name: | PSMD3 |
UniProt Entry Name: | PSMD3_HUMAN |