| バックグラウンド: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. |
| UniProt Protein Function: | RPT4: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family. |
| UniProt Protein Details: | Protein type:Proteasome complex; Protease Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: nucleoplasm; proteasome complex; membrane; nucleus; cytosol Molecular Function:protein binding, bridging; protein binding; ATPase activity; ATP binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle |
| NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62333 |
| NCBI GenInfo Identifier: | 51702772 |
| NCBI Gene ID: | 5706 |
| NCBI Accession: | P62333.1 |
| UniProt Secondary Accession: | P62333,P49719, Q6IBU3, Q92524, B2R975, |
| UniProt Related Accession: | P62333 |
| Molecular Weight: | 389 |
| NCBI Full Name: | 26S protease regulatory subunit 10B |
| NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
| NCBI Official Symbol: | PSMC6 |
| NCBI Official Synonym Symbols: | P44; p42; SUG2; CADP44; HEL-S-73 |
| NCBI Protein Information: | 26S protease regulatory subunit 10B; proteasome subunit p42; proteasome 26S subunit ATPase 6; conserved ATPase domain protein 44; epididymis secretory protein Li 73; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4 |
| UniProt Protein Name: | 26S protease regulatory subunit 10B |
| UniProt Synonym Protein Names: | 26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42 |
| Protein Family: | 26S protease regulatory |
| UniProt Gene Name: | PSMC6 |
| UniProt Entry Name: | PRS10_HUMAN |
