Anti-PSMB7 Antibody (CAB14771)

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SKU:
CAB14771
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-PSMB7 Antibody
抗体コード:CAB14771
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 44-200 of human PSMB7 (NP_002790.1).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:100
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, 293T, Mouse heart, Mouse testis, Mouse brain, Rat testis, Rat brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 44-200 of human PSMB7 (NP_002790.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:TTIA GVVY KDGI VLGA DTRA TEGM VVAD KNCS KIHF ISPN IYCC GAGT AADT DMTT QLIS SNLE LHSL STGR LPRV VTAN RMLK QMLF RYQG YIGA ALVL GGVD VTGP HLYS IYPH GSTD KLPY VTMG SGSL AAMA VFED KFRP DMEE EEAK NLVS E
遺伝子ID:5695
Uniprot:Q99436
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:15kDa/29kDa
観察された分子量:30kDa
同義語:PSMB7, Z
バックグラウンド:The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14.
UniProt Protein Function:PSMB7: a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. Not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
UniProt Protein Details:

Protein type:Protease; Proteasome complex; EC 3.4.25.1

Chromosomal Location of Human Ortholog: 9q34.11-q34.12

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex

Molecular Function:protein binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway

NCBI Summary:The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
UniProt Code:Q99436
NCBI GenInfo Identifier:17380263
NCBI Gene ID:5695
NCBI Accession:Q99436.1
UniProt Secondary Accession:Q99436,Q5TBG6, Q96AG8, Q9BWA7, B4E0P1,
UniProt Related Accession:Q99436
Molecular Weight:15,323 Da
NCBI Full Name:Proteasome subunit beta type-7
NCBI Synonym Full Names:proteasome subunit beta 7
NCBI Official Symbol:PSMB7  
NCBI Official Synonym Symbols:Z  
NCBI Protein Information:proteasome subunit beta type-7
UniProt Protein Name:Proteasome subunit beta type-7
UniProt Synonym Protein Names:Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z
Protein Family:Proteasome
UniProt Gene Name:PSMB7  
UniProt Entry Name:PSB7_HUMAN
Anti-PSMB7 Antibody (CAB14771)Western blot analysis of extracts of various cell lines, using PSMB7 antibody (CAB14771) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-PSMB7 Antibody (CAB14771)Immunofluorescence analysis of C6 cells using PSMB7 Polyclonal Antibody (CAB14771) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-PSMB7 Antibody (CAB14771)Immunofluorescence analysis of NIH-3T3 cells using PSMB7 Polyclonal Antibody (CAB14771) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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