| UniProt Protein Function: | PSG2: Belongs to the immunoglobulin superfamily. CEA family |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.1-q13.2 |
| NCBI Summary: | The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009] |
| UniProt Code: | P11465 |
| NCBI GenInfo Identifier: | 108935879 |
| NCBI Gene ID: | 5670 |
| NCBI Accession: | P11465.2 |
| UniProt Secondary Accession: | P11465,Q8TCD9, Q9UEA4, Q9UQ78, |
| UniProt Related Accession: | P11465 |
| Molecular Weight: | 37,216 Da |
| NCBI Full Name: | Pregnancy-specific beta-1-glycoprotein 2 |
| NCBI Synonym Full Names: | pregnancy specific beta-1-glycoprotein 2 |
| NCBI Official Symbol: | PSG2 |
| NCBI Official Synonym Symbols: | CEA; PSG1; PSBG2 |
| NCBI Protein Information: | pregnancy-specific beta-1-glycoprotein 2 |
| UniProt Protein Name: | Pregnancy-specific beta-1-glycoprotein 2 |
| UniProt Synonym Protein Names: | Pregnancy-specific beta-1 glycoprotein E; PS-beta-E |
| Protein Family: | Pregnancy-specific beta-1-glycoprotein |
| UniProt Gene Name: | PSG2 |
| UniProt Entry Name: | PSG2_HUMAN |
