Anti-PRSS2 Antibody (CAB7923)
- SKU:
- CAB7923
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PRSS2 Antibody |
| 抗体コード: | CAB7923 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse spleen, Mouse skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IVGG YICE ENSV PYQV SLNS GYHF CGGS LISE QWVV SAGH CYKS RIQV RLGE HNIE VLEG NEQF INAA KIIR HPKY NSRT LDND ILLI KLSS PAVI NSRV SAIS LPTA PPAA GTES LISG WGNT LSSG ADYP DELQ CLDA PVLS QAEC EASY PGKI TNNM FCVG FLEG GKDS CQGD SGGP VVSN GELQ GIVS WGYG CAQK NRPG VYTK VYNY VDWI KDTI AANS |
| 遺伝子ID: | 5645 |
| Uniprot: | P07478 |
| セルラーロケーション: | Secreted, extracellular space |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 26kDa |
| 同義語: | PRSS2, TRY2, TRY8, TRYP2, trypsin-2 |
| バックグラウンド: | This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Secreted, signal peptide; Calcium-binding; Secreted; EC 3.4.21.4; Extracellular matrix; Protease Chromosomal Location of Human Ortholog: 7q34 Cellular Component: extracellular matrix; extracellular region; extracellular space Molecular Function:calcium ion binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: collagen catabolic process; digestion; extracellular matrix disassembly; positive regulation of cell adhesion; positive regulation of cell growth; proteolysis Disease: Pancreatitis, Hereditary |
| NCBI Summary: | This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015] |
| UniProt Code: | P07478 |
| NCBI GenInfo Identifier: | 136413 |
| NCBI Gene ID: | 5645 |
| NCBI Accession: | P07478.1 |
| UniProt Related Accession: | P07478 |
| Molecular Weight: | 26,488 Da |
| NCBI Full Name: | Trypsin-2 |
| NCBI Synonym Full Names: | protease, serine 2 |
| NCBI Official Symbol: | PRSS2 |
| NCBI Official Synonym Symbols: | TRY2; TRY8; TRYP2 |
| NCBI Protein Information: | trypsin-2 |
| UniProt Protein Name: | Trypsin-2 |
| UniProt Synonym Protein Names: | Anionic trypsinogen; Serine protease 2; Trypsin II |
| Protein Family: | Trypsin |
| UniProt Gene Name: | PRSS2 |
| UniProt Entry Name: | TRY2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRSS2 antibody (CAB7923) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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