Anti-PRSS1 Antibody (CAB1242)
- SKU:
- CAB1242
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PRSS1 Antibody |
| 抗体コード: | CAB1242 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS1 (NP_002760.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, Mouse spleen, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS1 (NP_002760.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IVGG YNCE ENSV PYQV SLNS GYHF CGGS LINE QWVV SAGH CYKS RIQV RLGE HNIE VLEG NEQF INAA KIIR HPQY DRKT LNND IMLI KLSS RAVI NARV STIS LPTA PPAT GTKC LISG WGNT ASSG ADYP DELQ CLDA PVLS QAKC EASY PGKI TSNM FCVG FLEG GKDS CQGD SGGP VVCN GQLQ GVVS WGDG CAQK NKPG VYTK VYNY VKWI KNTI AANS |
| 遺伝子ID: | 5644 |
| Uniprot: | P07477 |
| セルラーロケーション: | Secreted, extracellular space |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 35kDa |
| 同義語: | PRSS1, TRP1, TRY1, TRY4, TRYP1, trypsin-1 |
| バックグラウンド: | This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. |
| UniProt Protein Function: | trypsin 1: Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. Defects in PRSS1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.4; Protease; Secreted Chromosomal Location of Human Ortholog: 7q34 Cellular Component: extracellular region Molecular Function:serine-type endopeptidase activity; metal ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; vitamin metabolic process; cobalamin metabolic process; digestion; proteolysis; water-soluble vitamin metabolic process Disease: Trypsinogen Deficiency; Pancreatitis, Hereditary |
| NCBI Summary: | This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07477 |
| NCBI GenInfo Identifier: | 136408 |
| NCBI Gene ID: | 5644 |
| NCBI Accession: | P07477.1 |
| UniProt Secondary Accession: | P07477,Q5NV57, Q7M4N3, Q7M4N4, Q92955, Q9HAN4, Q9HAN5 Q9HAN6, Q9HAN7, A1A509, A6NJ71, B2R5I5, |
| UniProt Related Accession: | P07477 |
| Molecular Weight: | 26,558 Da |
| NCBI Full Name: | Trypsin-1 |
| NCBI Synonym Full Names: | protease, serine, 1 (trypsin 1) |
| NCBI Official Symbol: | PRSS1 |
| NCBI Official Synonym Symbols: | TRP1; TRY1; TRY4; TRYP1 |
| NCBI Protein Information: | trypsin-1; beta-trypsin; trypsinogen 1; trypsinogen A; digestive zymogen; cationic trypsinogen; nonfunctional trypsin 1 |
| UniProt Protein Name: | Trypsin-1 |
| UniProt Synonym Protein Names: | Beta-trypsin; Cationic trypsinogen; Serine protease 1; Trypsin ICleaved into the following 2 chains:Alpha-trypsin chain 1; Alpha-trypsin chain 2 |
| Protein Family: | Tripeptidyl aminopeptidase |
| UniProt Gene Name: | PRSS1 |
| UniProt Entry Name: | TRY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRSS1 antibody (CAB1242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PRSS1 antibody (CAB1242) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using PRSS1 antibody (CAB1242) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using PRSS1 antibody (CAB1242) at dilution of 1:100 (40x lens). |
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