Anti-PRRX1 Antibody (CAB10237)
- SKU:
- CAB10237
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PRRX1 Antibody |
| 抗体コード: | CAB10237 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PRRX1 (NP_073207.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse heart, Mouse brain, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PRRX1 (NP_073207.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTSS YGHV LERQ PALG GRLD SPGN LDTL QAKK NFSV SHLL DLEE AGDM VAAQ ADEN VGEA GRSL LESP GLTS GSDT PQQD NDQL NSEE KK |
| 遺伝子ID: | 5396 |
| Uniprot: | P54821 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 24kDa/27kDa |
| 観察された分子量: | 27kDa |
| 同義語: | PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1 |
| バックグラウンド: | The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. |
| UniProt Protein Function: | PRRX1: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. Defects in PRRX1 are the cause of agnathia-otocephaly complex (AGOTC). AGOTC is a rare condition characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary, and cardiovascular anomalies, and situs inversus have been reported. The disorder is almost always lethal. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q24 Cellular Component: nucleolus; nucleus Molecular Function:transcription coactivator activity Disease: Agnathia-otocephaly Complex |
| NCBI Summary: | The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P54821 |
| NCBI GenInfo Identifier: | 6174916 |
| NCBI Gene ID: | 5396 |
| NCBI Accession: | P54821.2 |
| UniProt Secondary Accession: | P54821,O60807, B5BUM7, |
| UniProt Related Accession: | P54821 |
| Molecular Weight: | 24,396 Da |
| NCBI Full Name: | Paired mesoderm homeobox protein 1 |
| NCBI Synonym Full Names: | paired related homeobox 1 |
| NCBI Official Symbol: | PRRX1 |
| NCBI Official Synonym Symbols: | PMX1; PRX1; AGOTC; PHOX1; PRX-1 |
| NCBI Protein Information: | paired mesoderm homeobox protein 1 |
| UniProt Protein Name: | Paired mesoderm homeobox protein 1 |
| UniProt Synonym Protein Names: | Homeobox protein PHOX1; Paired-related homeobox protein 1; PRX-1 |
| Protein Family: | Paired mesoderm homeobox protein |
| UniProt Gene Name: | PRRX1 |
| UniProt Entry Name: | PRRX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRRX1 antibody (CAB10237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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