Anti-PRPF8 Antibody (CAB6053)
- SKU:
- CAB6053
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-PRPF8 Antibody |
抗体コード: | CAB6053 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRPF8 (NP_006436.3). |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Jurkat |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRPF8 (NP_006436.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGV FPYR GPGN PVPG PLAP LPDY MSEE KLQE KARK WQQL QAKR YAEK RKFG FVDA QKED MPPE HVRK IIRD HGDM TNRK FRHD KRVY LGAL KYMP HAVL |
遺伝子ID: | 10594 |
Uniprot: | Q6P2Q9 |
セルラーロケーション: | Nucleus speckle |
計算された分子量: | 273kDa |
観察された分子量: | 274kDa |
同義語: | PRPF8, HPRP8, PRP8, PRPC8, RP13, SNRNP220, PRPF8 |
バックグラウンド: | Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. |
UniProt Protein Function: | Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. |
NCBI Summary: | Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q6P2Q9 |
NCBI GenInfo Identifier: | 67460824 |
NCBI Gene ID: | 10594 |
NCBI Accession: | Q6P2Q9.2 |
UniProt Related Accession: | Q6P2Q9 |
Molecular Weight: | |
NCBI Full Name: | Pre-mRNA-processing-splicing factor 8 |
NCBI Synonym Full Names: | pre-mRNA processing factor 8 |
NCBI Official Symbol: | PRPF8 |
NCBI Official Synonym Symbols: | PRP8; RP13; HPRP8; PRPC8; SNRNP220 |
NCBI Protein Information: | pre-mRNA-processing-splicing factor 8 |
UniProt Protein Name: | Pre-mRNA-processing-splicing factor 8 |
UniProt Synonym Protein Names: | 220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220 |
Protein Family: | Pre-mRNA-splicing factor |
UniProt Gene Name: | PRPF8 |
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