| UniProt Protein Function: | OGA: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Acetyltransferase; Hydrolase; EC 3.2.1.169; EC 3.2.1.52 Chromosomal Location of Human Ortholog: 10q24.1-q24.3 Cellular Component: membrane; cytosol; nucleus Molecular Function:beta-N-acetylglucosaminidase activity; histone acetyltransferase activity; hyalurononglucosaminidase activity Biological Process: positive regulation of DNA metabolic process; positive regulation of protein complex disassembly; dATP metabolic process; positive regulation of proteolysis; protein deglycosylation; N-acetylglucosamine metabolic process; positive regulation of insulin secretion; positive regulation of growth hormone secretion; positive regulation of glucose import; negative regulation of protein amino acid glycosylation; positive regulation of mitochondrial depolarization; response to steroid hormone stimulus; positive regulation of cell killing; glycoprotein catabolic process; histone acetylation; protein targeting to membrane; aging |
| NCBI Summary: | The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O60502 |
| NCBI GenInfo Identifier: | 215490056 |
| NCBI Gene ID: | 10724 |
| NCBI Accession: | NP_001135906.1 |
| UniProt Secondary Accession: | O60502,O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0, B7WPB9 D3DR79, E9PGF9, |
| UniProt Related Accession: | O60502 |
| Molecular Weight: | 96,932 Da |
| NCBI Full Name: | bifunctional protein NCOAT isoform b |
| NCBI Synonym Full Names: | meningioma expressed antigen 5 (hyaluronidase) |
| NCBI Official Symbol: | MGEA5 |
| NCBI Official Synonym Symbols: | OGA; MEA5; NCOAT |
| NCBI Protein Information: | bifunctional protein NCOAT; O-GlcNAcase; hyaluronidase in meningioma; meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase |
| UniProt Protein Name: | Bifunctional protein NCOAT |
| UniProt Synonym Protein Names: | Meningioma-expressed antigen 5; Nuclear cytoplasmic O-GlcNAcase and acetyltransferaseIncluding the following 2 domains:Protein O-GlcNAcase (EC:3.2.1.169)Alternative name(s):Glycoside hydrolase O-GlcNAcase; Hexosaminidase C; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; O-GlcNAcase; OGA |
| Protein Family: | Protein O-GlcNAcase |
| UniProt Gene Name: | MGEA5 |
| UniProt Entry Name: | NCOAT_HUMAN |
