Anti-PROP1 Antibody (CAB16962)
- SKU:
- CAB16962
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-PROP1 Antibody |
| 抗体コード: | CAB16962 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PROP1 (NP_006252.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GGGR SRFS PQGG QRGR PHSR RRHR TTFS PVQL EQLE SAFG RNQY PDIW ARES LARD TGLS EARI QVWF QNRR AKQR KQER SLLQ PLAH LSPA AFSS FLPE S |
| 遺伝子ID: | 5626 |
| Uniprot: | O75360 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | PROP1, CPHD2, PROP-1 |
| バックグラウンド: | This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. |
| UniProt Protein Function: | PROP1: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. Defects in PROP1 are the cause of pituitary hormone deficiency combined type 2 (CPHD2); also known as pituitary dwarfism III. It is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones. Belongs to the paired homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: transcription factor complex; nucleus Molecular Function:protein C-terminus binding; protein binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding Biological Process: blood vessel development; cell migration; central nervous system development; dorsal/ventral pattern formation; hypophysis morphogenesis; positive regulation of transcription from RNA polymerase II promoter; hypothalamus cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; somatotropin secreting cell differentiation; negative regulation of apoptosis Disease: Pituitary Hormone Deficiency, Combined, 2 |
| NCBI Summary: | This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O75360 |
| NCBI GenInfo Identifier: | 262359909 |
| NCBI Gene ID: | 5626 |
| NCBI Accession: | NP_006252.3 |
| UniProt Related Accession: | O75360 |
| Molecular Weight: | 24,984 Da |
| NCBI Full Name: | homeobox protein prophet of Pit-1 |
| NCBI Synonym Full Names: | PROP paired-like homeobox 1 |
| NCBI Official Symbol: | PROP1 |
| NCBI Official Synonym Symbols: | CPHD2; PROP-1 |
| NCBI Protein Information: | homeobox protein prophet of Pit-1; pituitary-specific homeodomain factor; prophet of Pit1, paired-like homeodomain transcription factor |
| UniProt Protein Name: | Homeobox protein prophet of Pit-1 |
| UniProt Synonym Protein Names: | Pituitary-specific homeodomain factor |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | PROP1 |
| UniProt Entry Name: | PROP1_HUMAN |