Anti-PROKR2 Antibody (CAB2960)
- SKU:
- CAB2960
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PROKR2 Antibody |
| 抗体コード: | CAB2960 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human PROKR2 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, SKOV3, 293T, Mouse thymus |
| 免疫原: | A synthetic peptide of human PROKR2 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 128674 |
| Uniprot: | Q8NFJ6 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 43kDa |
| 観察された分子量: | 50kDa |
| 同義語: | PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3 |
| バックグラウンド: | Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. |
| UniProt Protein Function: | PROKR2: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Defects in PROKR2 are the cause of Kallmann syndrome type 3 (KAL3); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL3 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 20p12.3 Cellular Component: integral to membrane; plasma membrane Molecular Function:neuropeptide Y receptor activity Biological Process: circadian rhythm; neuropeptide signaling pathway Disease: Hypogonadotropic Hypogonadism 3 With Or Without Anosmia |
| NCBI Summary: | Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NFJ6 |
| NCBI GenInfo Identifier: | 33112425 |
| NCBI Gene ID: | 128674 |
| NCBI Accession: | Q8NFJ6.1 |
| UniProt Secondary Accession: | Q8NFJ6,Q2M3C0, Q5TDY1, Q9NTT0, A5JUU1, |
| UniProt Related Accession: | Q8NFJ6 |
| Molecular Weight: | 384 |
| NCBI Full Name: | Prokineticin receptor 2 |
| NCBI Synonym Full Names: | prokineticin receptor 2 |
| NCBI Official Symbol: | PROKR2 |
| NCBI Official Synonym Symbols: | HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3 |
| NCBI Protein Information: | prokineticin receptor 2; PK-R2; G protein-coupled receptor 73-like 1 |
| UniProt Protein Name: | Prokineticin receptor 2 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 73-like 1; GPR73b; GPRg2 |
| Protein Family: | Prokineticin receptor |
| UniProt Gene Name: | PROKR2 |
| UniProt Entry Name: | PKR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PROKR2 antibody (CAB2960) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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