Anti-PROK2 Antibody (CAB6705)
- SKU:
- CAB6705
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PROK2 Antibody |
| 抗体コード: | CAB6705 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-129 of human PROK2 (NP_001119600.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, HL-60, HepG2, Mouse liver, Rat thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-129 of human PROK2 (NP_001119600.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LTPR AGDA AVIT GACD KDSQ CGGG MCCA VSIW VKSI RICT PMGK LGDS CHPL TRKN NFGN GRQE RRKR KRSK RKKE VPFF GRRM HHTC PCLP GLAC LRTS FNRF ICLA QK |
| 遺伝子ID: | 60675 |
| Uniprot: | Q9HC23 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 11kDa/14kDa |
| 観察された分子量: | 17kDa |
| 同義語: | PROK2, BV8, HH4, KAL4, MIT1, PK2 |
| バックグラウンド: | This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PROK2: May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle. Defects in PROK2 are the cause of Kallmann syndrome type 4 (KAL4); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. KAL4 patients have variable degrees of olfactory and reproductive dysfunction, but do not show any of the occasional clinical anomalies reported in Kallmann syndrome such as renal agenesis, cleft lip/palate, selective tooth agenesis, and bimanual synkinesis. Belongs to the AVIT (prokineticin) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p13 Cellular Component: extracellular region Molecular Function:G-protein-coupled receptor binding Biological Process: circadian rhythm; activation of MAPK activity; sensory perception of pain; chemotaxis; cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; spermatogenesis; angiogenesis; positive regulation of smooth muscle contraction; inflammatory response; negative regulation of apoptosis Disease: Hypogonadotropic Hypogonadism 4 With Or Without Anosmia |
| NCBI Summary: | This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HC23 |
| NCBI GenInfo Identifier: | 18202953 |
| NCBI Gene ID: | 60675 |
| NCBI Accession: | Q9HC23.2 |
| UniProt Secondary Accession: | Q9HC23,Q53Z79, Q6ISR0, |
| UniProt Related Accession: | Q9HC23 |
| Molecular Weight: | Calculated MW: 11kDa/14kDaObserved MW: 17kDa |
| NCBI Full Name: | Prokineticin-2 |
| NCBI Synonym Full Names: | prokineticin 2 |
| NCBI Official Symbol: | PROK2 |
| NCBI Official Synonym Symbols: | BV8; HH4; PK2; KAL4; MIT1 |
| NCBI Protein Information: | prokineticin-2; protein Bv8 homolog |
| UniProt Protein Name: | Prokineticin-2 |
| UniProt Synonym Protein Names: | Protein Bv8 homolog |
| Protein Family: | Prokineticin |
| UniProt Gene Name: | PROK2 |
| UniProt Entry Name: | PROK2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PROK2 antibody (CAB6705) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using PROK2 antibody (CAB6705) at dilution of 1:100 (40x lens). |
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