Anti-PRMT8 Antibody (CAB18440)[KO Validated]
![Anti-PRMT8 Antibody (CAB18440)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/24621/24469/anti-prmt8-antibody-cab18440ko-validated__21255__86677.1645805946.jpg?c=1 "Anti-PRMT8 Antibody (CAB18440)[KO Validated]")
- SKU:
- CAB18440
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
![Anti-PRMT8 Antibody (CAB18440)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/24621/24469/anti-prmt8-antibody-cab18440ko-validated__21255__86677.1645805946.jpg?c=1&imbypass=on "Anti-PRMT8 Antibody (CAB18440)[KO Validated]")
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Description
| 抗体名: | Anti-PRMT8 Antibody [KO Validated] |
| 抗体コード: | CAB18440 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PRMT8. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Mouse brain, Rat brain |
| 免疫原: | Recombinant protein of human PRMT8. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 56341 |
| Uniprot: | Q9NR22 |
| セルラーロケーション: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| 計算された分子量: | 44kDa/45kDa |
| 観察された分子量: | 42KDa |
![Anti-PRMT8 Antibody [KO Validated] (CAB18440)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/v/108/A18440_1__93439.jpg) | Western blot analysis of extracts of various cell lines, using PRMT8 antibody (CAB18440) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
![Anti-PRMT8 Antibody [KO Validated] (CAB18440)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/t/935/A18440_2__70719.jpg) | Western blot analysis of extracts from normal (control) and PRMT8 Rabbit pAb knockout (KO) 293T cells, using PRMT8 Rabbit pAb antibody (CAB18440) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | HRMT1L3, HRMT1L4, PRMT8 |
| バックグラウンド: | Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | PRMT8: Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase, protein arginine; EC 2.1.1.-; Methyltransferase Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytosol; nucleus; plasma membrane Molecular Function:histone-arginine N-methyltransferase activity; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity Biological Process: histone methylation; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; regulation of protein binding; regulation of transcription, DNA-dependent |
| NCBI Summary: | Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NR22 |
| NCBI GenInfo Identifier: | 88983969 |
| NCBI Gene ID: | 56341 |
| NCBI Accession: | Q9NR22.2 |
| UniProt Secondary Accession: | Q9NR22,Q8TBJ8, B2RDP0, |
| UniProt Related Accession: | Q9NR22 |
| Molecular Weight: | 44,169 Da |
| NCBI Full Name: | Protein arginine N-methyltransferase 8 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 8 |
| NCBI Official Symbol: | PRMT8 |
| NCBI Official Synonym Symbols: | HRMT1L3; HRMT1L4 |
| NCBI Protein Information: | protein arginine N-methyltransferase 8 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 8 |
| UniProt Synonym Protein Names: | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 |
| Protein Family: | Protein arginine N-methyltransferase |
| UniProt Gene Name: | PRMT8 |
| UniProt Entry Name: | ANM8_HUMAN |