Anti-PRLR Antibody (CAB10513)
- SKU:
- CAB10513
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PRLR Antibody |
| 抗体コード: | CAB10513 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human PRLR (NP_000940.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, MCF7, Mouse ovary |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human PRLR (NP_000940.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QLPP GKPE IFKC RSPN KETF TCWW RPGT DGGL PTNY SLTY HREG ETLM HECP DYIT GGPN SCHF GKQY TSMW RTYI MMVN ATNQ MGSS FSDE LYVD VTYI VQPD PPLE LAVE VKQP EDRK PYLW IKWS PPTL IDLK TGWF TLLY EIRL KPEK AAEW EIHF AGQQ TEFK ILSL HPGQ KYLV QVRC KPDH GYWS AWSP ATFI QIPS DFTM ND |
| 遺伝子ID: | 5618 |
| Uniprot: | P16471 |
| セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 24-42kDa/57kDa/69kDa |
| 観察された分子量: | 70kDa |
| 同義語: | PRLR, HPRL, MFAB, hPRLrI |
| バックグラウンド: | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. |
| UniProt Protein Function: | PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 5p13.2 Cellular Component: cell surface; plasma membrane Molecular Function:peptide hormone binding; protein binding Biological Process: embryo implantation; transmembrane receptor protein tyrosine kinase activation (dimerization) Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast |
| NCBI Summary: | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] |
| UniProt Code: | P16471 |
| NCBI GenInfo Identifier: | 130321 |
| NCBI Gene ID: | 5618 |
| NCBI Accession: | P16471.1 |
| UniProt Secondary Accession: | P16471,Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87 Q9UHJ5, B2R882, D1MDP1, |
| UniProt Related Accession: | P16471 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | Prolactin receptor |
| NCBI Synonym Full Names: | prolactin receptor |
| NCBI Official Symbol: | PRLR |
| NCBI Official Synonym Symbols: | HPRL; MFAB; hPRLrI |
| NCBI Protein Information: | prolactin receptor |
| UniProt Protein Name: | Prolactin receptor |
| Protein Family: | Prolactin receptor |
| UniProt Gene Name: | PRLR |
 | Western blot analysis of extracts of various cell lines, using PRLR antibody (CAB10513) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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