Anti-PRKX Antibody (CAB15305)
- SKU:
- CAB15305
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-PRKX Antibody |
| 抗体コード: | CAB15305 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 239-358 of human PRKX (NP_005035.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A549 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 239-358 of human PRKX (NP_005035.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SGFP PFFD DNPF GIYQ KILA GKID FPRH LDFH VKDL IKKL LVVD RTRR LGNM KNGA NDVK HHRW FRSV DWEA VPQR KLKP PIVP KIAG DGDT SNFE TYPE NDWD TAAP VPQK DLEI FKNF |
| 遺伝子ID: | 5613 |
| Uniprot: | P51817 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 40kDa |
| 観察された分子量: | 41kDa |
| 同義語: | PRKX, PKX1 |
| バックグラウンド: | This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. |
| UniProt Protein Function: | PRKX: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family Chromosomal Location of Human Ortholog: Xp22.3 Cellular Component: cytoplasm; nucleus Molecular Function:cAMP-dependent protein kinase activity; protein binding Biological Process: angiogenesis; cell adhesion; cell-substrate adhesion; endothelial cell migration; endothelial cell proliferation; myeloid cell differentiation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; regulation of cell adhesion; regulation of cell migration |
| NCBI Summary: | This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010] |
| UniProt Code: | P51817 |
| NCBI GenInfo Identifier: | 1709648 |
| NCBI Gene ID: | 5613 |
| NCBI Accession: | P51817.1 |
| UniProt Related Accession: | P51817 |
| Molecular Weight: | 40,896 Da |
| NCBI Full Name: | cAMP-dependent protein kinase catalytic subunit PRKX |
| NCBI Synonym Full Names: | protein kinase, X-linked |
| NCBI Official Symbol: | PRKX |
| NCBI Official Synonym Symbols: | PKX1 |
| NCBI Protein Information: | cAMP-dependent protein kinase catalytic subunit PRKX |
| UniProt Protein Name: | cAMP-dependent protein kinase catalytic subunit PRKX |
| UniProt Synonym Protein Names: | Protein kinase PKX1 |
| Protein Family: | cAMP-dependent protein kinase |
| UniProt Gene Name: | PRKX |
| UniProt Entry Name: | PRKX_HUMAN |
 | Western blot analysis of extracts of A549 cells, using PRKX antibody (CAB15305) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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