| UniProt Protein Function: | PRKD2: a calcium-independent, phospholipid-dependent CAMK kinase of the PKD family. Activated by diacylglycerol and phorbol esters. may play a role in carcinoid tumor progression. |
| UniProt Protein Details: | Protein type:EC 2.7.11.13; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; PKD family Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm; nucleus; plasma membrane Molecular Function:ATP binding; metal ion binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; adaptive immune response; angiogenesis; cell adhesion; cell death; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell adhesion; positive regulation of endothelial cell proliferation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of interleukin-2 production; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of T cell receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZL6 |
| NCBI GenInfo Identifier: | 296434570 |
| NCBI Gene ID: | 25865 |
| NCBI Accession: | Q9BZL6.2 |
| UniProt Secondary Accession: | Q9BZL6,Q8NCK8, Q8TB08, Q9P0T6, Q9Y3X8, M0R2R2, |
| UniProt Related Accession: | Q9BZL6 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein kinase D2 |
| NCBI Synonym Full Names: | protein kinase D2 |
| NCBI Official Symbol: | PRKD2 |
| NCBI Official Synonym Symbols: | PKD2; HSPC187; nPKC-D2 |
| NCBI Protein Information: | serine/threonine-protein kinase D2 |
| UniProt Protein Name: | Serine/threonine-protein kinase D2 |
| UniProt Synonym Protein Names: | nPKC-D2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | PRKD2 |
| UniProt Entry Name: | KPCD2_HUMAN |
