Anti-PREX1 Antibody (CAB18344)
- SKU:
- CAB18344
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| 抗体名: | Anti-PREX1 Antibody |
| 抗体コード: | CAB18344 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PREX1. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human PREX1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 57580 |
| Uniprot: | Q8TCU6 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | P-REX1, PREX1 |
| バックグラウンド: |
| UniProt Protein Function: | PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEFs; GEFs, Rac/Rho Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: cytoplasm; cytosol; dendritic shaft; growth cone; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane Molecular Function:enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of dendrite development; regulation of Rho protein signal transduction; superoxide metabolic process; T cell differentiation |
| NCBI Summary: | The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TCU6 |
| NCBI GenInfo Identifier: | 148886999 |
| NCBI Gene ID: | 57580 |
| NCBI Accession: | Q8TCU6.3 |
| UniProt Secondary Accession: | Q8TCU6,Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55 Q9H4Q6, Q9P2D2, Q9UGQ4, E1P5X9, |
| UniProt Related Accession: | Q8TCU6 |
| Molecular Weight: | 175,847 Da |
| NCBI Full Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| NCBI Synonym Full Names: | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 |
| NCBI Official Symbol: | PREX1 |
| NCBI Official Synonym Symbols: | P-REX1 |
| NCBI Protein Information: | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| UniProt Protein Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| Protein Family: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein |
| UniProt Gene Name: | PREX1 |
| UniProt Entry Name: | PREX1_HUMAN |