Anti-PRDM9 Antibody (CAB20340)
- SKU:
- CAB20340
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PFM6
- Synonyms:
- KMT8B
- Synonyms:
- MSBP3
- Synonyms:
- ZNF899
- Synonyms:
- MEISETZ
Frequently bought together:
Description
I抗体名: | PRDM9 Rabbit pAb |
抗体コード: | CAB20340 |
サイズ: | 50uL, 100uL |
同義語: | PFM6, KMT8B, MSBP3, ZNF899, MEISETZ |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human PRDM9. |
申し込み: | WB |
推奨される希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse stomach, Rat testis |
免疫原: | Recombinant protein of human PRDM9. |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 56979 |
Uniprot: | Q9NQV7 |
計算された分子量: | 103kDa |
観察された分子量: | 103KDa |
バックグラウンド: | The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. |