Anti-PPP6R2 Antibody (CAB8359)

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SKU:
CAB8359
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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Description

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抗体名:Anti-PPP6R2 Antibody
抗体コード:CAB8359
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 640-959 of human PPP6R2 (NP_001229827.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:HepG2, 293T, Jurkat
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 640-959 of human PPP6R2 (NP_001229827.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:EDSD TRCA ARVM ARPR FGAP HASE SCSK NGPE RGGQ DGKA SLEA HRDA PGAG APPA PGKK EAPP VEGD SEGA MWTA VFDE PANS TPTA PGVV RDVG SSVW AAGT SAPE EKGW AKFT DFQP FCCS ESGP RCSS PVDT ECSH AEGS RSQG PEKA FSPA SPCA WNVC VTRK APLL ASDS SSSG GSHS EDGD QKAA SAMD AVSR GPGR EAPP LPTV ARTE EAVG RVGC ADSR LLSP ACPA PKEV TAAP AVAV PPEA TVAI TTAL SKAG PAIP TPAV SSAL AVAV PLGP IMAV TAAP AMVA TLGT VTKD GKTD APPE GAAL NGPV
遺伝子ID:9701
Uniprot:O75170
セルラーロケーション:Cytoplasm
計算された分子量:98kDa/101kDa/104kDa
観察された分子量:105kDa
同義語:PPP6R2, KIAA0685, PP6R2, SAP190, SAPS2
バックグラウンド:The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment.
UniProt Protein Function:SAPS2: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Belongs to the SAPS family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: cytoplasm; intracellular membrane-bound organelle

Molecular Function:protein binding

NCBI Summary:Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
UniProt Code:O75170
NCBI GenInfo Identifier:166214976
NCBI Gene ID:9701
NCBI Accession:O75170.2
UniProt Secondary Accession:O75170,Q5U5P3, Q7Z2L2, Q7Z5G5, Q7Z731, Q9UGB9, A6PVG3 B7Z7T3,
UniProt Related Accession:O75170
Molecular Weight:98,126 Da
NCBI Full Name:Serine/threonine-protein phosphatase 6 regulatory subunit 2
NCBI Synonym Full Names:protein phosphatase 6 regulatory subunit 2
NCBI Official Symbol:PPP6R2  
NCBI Official Synonym Symbols:PP6R2; SAPS2; SAP190; KIAA0685  
NCBI Protein Information:serine/threonine-protein phosphatase 6 regulatory subunit 2
UniProt Protein Name:Serine/threonine-protein phosphatase 6 regulatory subunit 2
UniProt Synonym Protein Names:SAPS domain family member 2
Protein Family:Serine/threonine-protein phosphatase
UniProt Gene Name:PPP6R2  
UniProt Entry Name:PP6R2_HUMAN
Anti-PPP6R2 Polyclonal Antibody (CAB8359)Western blot analysis of extracts of various cell lines, using PPP6R2 antibody (CAB8359) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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