Anti-PPP3CC Antibody (CAB7714)

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SKU:
CAB7714
Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

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抗体名:Anti-PPP3CC Antibody
抗体コード:CAB7714
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 373-512 of human PPP3CC (NP_005596.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Mouse, Rat
ポジティブサンプル:Mouse testis, Rat brain
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 373-512 of human PPP3CC (NP_005596.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:LISD DEAE GSTT VRKE IIRN KIRA IGKM ARVF SILR QESE SVLT LKGL TPTG TLPL GVLS GGKQ TIET ATVE AVEA REAI RGFS LQHK IRSF EEAR GLDR INER MPPR KDSI HAGG PMKS VTSA HSHA AHRS DQGK KAHS
遺伝子ID:5533
Uniprot:P48454
セルラーロケーション:
計算された分子量:57kDa/58kDa/59kDa
観察された分子量:58kDa
同義語:PPP3CC, CALNA3, CNA3, PP2Bgamma
バックグラウンド:Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:PPP3CC: a calmodulin-dependent Ser/Thr phosphatase also known as calcineurin A gamma. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.
UniProt Protein Details:

Protein type:EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol

Molecular Function:calmodulin binding; metal ion binding; phosphoprotein phosphatase activity

Biological Process: dephosphorylation; apoptosis

NCBI Summary:Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:P48454
NCBI GenInfo Identifier:257051041
NCBI Gene ID:5533
NCBI Accession:P48454.3
UniProt Related Accession:P48454
Molecular Weight:
NCBI Full Name:Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
NCBI Synonym Full Names:protein phosphatase 3 catalytic subunit gamma
NCBI Official Symbol:PPP3CC  
NCBI Official Synonym Symbols:CNA3; CALNA3; PP2Bgamma  
NCBI Protein Information:serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
UniProt Protein Name:Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
UniProt Synonym Protein Names:CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform
UniProt Gene Name:PPP3CC  
UniProt Entry Name:PP2BC_HUMAN
Anti-PPP3CC Antibody (CAB7714)Western blot analysis of extracts of various cell lines, using PPP3CC antibody (CAB7714) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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